KMO
Kynurenine-3-monooxygenase
Kynurenine-3-monooxygenase (KMO) is an enzyme that plays a crucial role in the kynurenine pathway. It catalyzes the hydroxylation of kynurenine to 3-hydroxykynurenine, using molecular oxygen and NADPH as cofactors. This enzyme is mainly expressed in the liver and brain. In the brain, the kynurenine pathway is involved in the regulation of neurotransmitter levels and immune responses. Dysregulation of Kynurenine-3-monooxygenase activity has been implicated in various neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's disease, and depression[1][2][3].
Références:
- [1]. Smith JR, et al. Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors. Drug Discov Today. 2016 Feb;21(2):315-24. [Content Brief]
- [2]. Parrott JM, et al. Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology. Front Psychiatry. 2015 Aug 20;6:116. [Content Brief]
- [3]. Lu Y, et al. Kynurenine-3-monooxygenase: A new direction for the treatment in different diseases. Food Sci Nutr. 2020 Jan 20;8(2):711-719. [Content Brief]
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KMO Produits associés (11)
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Ro 61-8048
0 ImagesRo 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations.
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TES-1025
0 ImagesTES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
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GSK180
0 ImagesGSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism (IC50, ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition.
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Cannflavin A
0 ImagesCannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC50 = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line.
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GSK 366
0 ImagesGSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC50 values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMO’s substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H2O2) production and reduces H2O2 levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimer’s disease.
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KMO-IN-1
0 ImagesCat. No.: HY-182692CAS No.: 1953156-92-7
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CHDI-340246
0 ImagesCat. No.: HY-182456CAS No.: 1426319-74-5CHDI-340246 is an orally active kynurenine monooxygenase (KMO) inhibitor. CHDI-340246 blocks KMO activity, alters the metabolic flux of the kynurenine pathway, inhibits the production of 3-hydroxykynurenine and quinolinic acid, elevates the levels of kynurenine and kynurenic acid, and restores electrophysiological abnormalities in transgenic mouse models of Huntington's disease. CHDI-340246 can be used in studies related to Huntington's disease.
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Cannflavin A (Standard)
0 ImagesCat. No.: HY-W748591RCAS No.: 76735-57-4Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC50 = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line.
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JM6
0 ImagesCat. No.: HY-15500CAS No.: 1008119-83-2
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Ro 61-8048 (Standard)
0 ImagesRo 61-8048 (Standard) is the analytical standard of Ro 61-8048. This product is intended for research and analytical applications. Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations.
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