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Cat. No.: HY-149810

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AcrB-IN-2

AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.

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CAS No.: 2890177-90-7
Formule: C₃₀H₃₅NO₆
Masse moléculaire:505.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AcrB-IN-2 Chemical Structure

CAS No.: 2890177-90-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
- In Vivo
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Description

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In Vitro

AcrB-IN-2 (compound G6) (8-128 μg/mL) shows outstanding antibacterial synergism with at least one of the antibiotics (ERY, LEV and MIN). AcrB-IN-2 show antibacterial synergism with MIN, and reduces the MIC value of MIN by 4-fold at 64 μg/mL^[1].
AcrB-IN-2 (50 μM, 100 μM) shows strong inhibitory activity at the lowest concentration of 50 μM, to inhibit Nile Red efflux^[1].
AcrB-IN-2 (4-256 μg/mL) does not cause hemolysis of mice red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AcrB-IN-2 (compound G6) (128 μg/mL; 72 h) shows no significant and in vivo toxicity against Caenorhabditis elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2890177-90-7
Masse moléculaire 505.60
Formule C₃₀H₃₅NO₆
SMILES

COC1=CC=C(C=C1)OCCCOC2=CC=CC3=C2C=C(C4=C3OC(C)(CC4)C)C(N5CCOCC5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AcrB-IN-2

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AcrB-IN-2 Related Classifications

HY-149810 Related Classifications