CP 132484
CP 132484 is a rat 5-HT2A receptor agonist with a Ki of 1.1 nM and an IC50 of 2.8 nM, and it exhibits over 40-fold selectivity over rat 5-HT1A receptors and bovine 5-HT1D receptors. CP 132484 stimulates phosphoinositide hydrolysis and intracellular calcium mobilization. CP 132484 can be used for research into diseases such as glaucoma.
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- CAS No.: 143508-76-3
- Formule: C14H18N2O
- Masse moléculaire:230.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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5-HT2A Receptor 1.1 nM (Ki) |
5-HT2A Receptor 2.8 nM (IC50) |
CP 132484 (Compound 4a) (1 h) binds with high affinity to rat cortical 5-HT2A receptors, with a Ki of 1.1 nM and an IC50 of 2.8 nM[1].
CP 132484 (1 h) potently stimulates phosphoinositide hydrolysis in A7r5 rat vascular smooth muscle cells via activation of the 5-HT2A receptor, with an EC50 of 213 nM and a potency reaching 96% relative to serotonin[1].
CP 132484 stimulates calcium mobilization in A7r5 rat vascular smooth muscle cells by activating the 5-HT2a receptor, with an EC50 of 95.5 nM and a potency equivalent to 70% of that of serotonin[1].
CP 132484 (1 h) exhibits low affinity (IC50 = 8410 nM) and no agonist activity at cloned human 5-HT1A receptors expressed on CHO cell membranes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143508-76-3
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Masse moléculaire 230.31
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Formule C14H18N2O
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SMILES
O1C2=CC=C3C(C(=CN3C)CCN)=C2CCC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP 132484 Related Classifications
HY-184351 Related Classifications
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