L-DOPA-13C
Based on 1 publication(s) in Google Scholar
L-DOPA-13C is the 13C labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
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- Pureté: 99.77%
- CAS No.: 586971-29-1
- Formule: C813CH11NO4
- Masse moléculaire:198.18
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-DOPA-13C
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 586971-29-1
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Unlabeled Cas 59-92-7
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Appearance Solid
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Masse moléculaire 198.18
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Formule C813CH11NO4
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Color White to off-white
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SMILES
O[13C]([C@@H](N)CC1=CC(O)=C(C=C1)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
2023 Jun 20;4(6):101061. PMID: 37267943
Solvant et solubilité
0.1 M HCl : 20 mg/mL (100.92 mM; ultrasonic and warming and adjust pH to pH to 2 with HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10. [Content Brief]
[3]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 200814(4):273-80. Epub 2007 Nov 7. [Content Brief]
[4]. Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 310:237. [Content Brief]
[5]. Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 154(2):330-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M HCl | 1 mM | 5.0459 mL | 25.2296 mL | 50.4592 mL | 126.1480 mL |
| 5 mM | 1.0092 mL | 5.0459 mL | 10.0918 mL | 25.2296 mL | |
| 10 mM | 0.5046 mL | 2.5230 mL | 5.0459 mL | 12.6148 mL | |
| 15 mM | 0.3364 mL | 1.6820 mL | 3.3639 mL | 8.4099 mL | |
| 20 mM | 0.2523 mL | 1.2615 mL | 2.5230 mL | 6.3074 mL | |
| 25 mM | 0.2018 mL | 1.0092 mL | 2.0184 mL | 5.0459 mL | |
| 30 mM | 0.1682 mL | 0.8410 mL | 1.6820 mL | 4.2049 mL | |
| 40 mM | 0.1261 mL | 0.6307 mL | 1.2615 mL | 3.1537 mL | |
| 50 mM | 0.1009 mL | 0.5046 mL | 1.0092 mL | 2.5230 mL | |
| 60 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1025 mL | |
| 80 mM | 0.0631 mL | 0.3154 mL | 0.6307 mL | 1.5768 mL | |
| 100 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2615 mL |
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