Sitagliptin phosphate

(Synonyms: MK-0431 phosphate)
31 Cited Publications
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Based on 31 publication(s) in Google Scholar

Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes.

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  • Pureté: 99.88%
  • CAS No.: 654671-78-0
  • Formule: C16H18F6N5O5P
  • Masse moléculaire:505.31
  • Stockage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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Publications Citing Use of MedChemExpress (MCE) Sitagliptin phosphate

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In Vivo Efficacy StudyHistological Imaging/StainingIFRT-PCR
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • Histological Imaging/Staining
  • IF
  • RT-PCR

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