Mgrn1 - mahogunin, ring finger 1 Gene

Also Known as md; nc; mKIAA0544; 2610042J20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17237

Summary

Enables ubiquitin protein Ligase activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within protein polyubiquitination. Predicted to be located in endoplasmic reticulum. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; node; and skin. Orthologous to human MGRN1 (mahogunin ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Mgrn1 Products (8)

mRNA Protein Name
NM_001252437.1 NP_001239366.1 E3 ubiquitin-protein ligase MGRN1 isoform 1
NM_001357061.1 NP_001343990.1 E3 ubiquitin-protein ligase MGRN1 isoform 3
NM_001357062.1 NP_001343991.1 E3 ubiquitin-protein ligase MGRN1 isoform 4
NM_001379012.1 NP_001365941.1 E3 ubiquitin-protein ligase MGRN1 isoform 5
NM_001379013.1 NP_001365942.1 E3 ubiquitin-protein ligase MGRN1 isoform 6
NM_001379014.1 NP_001365943.1 E3 ubiquitin-protein ligase MGRN1 isoform 7
NM_001379015.1 NP_001365944.1 E3 ubiquitin-protein ligase MGRN1 isoform 2
NM_029657.4 NP_083933.1 E3 ubiquitin-protein ligase MGRN1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25342469 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
12560552 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
32966817 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
32966817 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
32966817 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
29290584 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
12560552 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
32966817 MGI
acts upstream of or within protein-containing complex assembly IDA
IDA: Inferred from direct assay
32966817 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
32966817 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
32966817 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
32966817 MGI
part of ubiquitin ligase complex IPI
IPI: Inferred from physical interaction
32966817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MGRN1

  • RING-type E3 ubiquitin transferase MGRN1

  • mahoganoid

  • mahogunin RING finger protein 1

  • probable E3 ubiquitin-protein ligase MGRN1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08415 MGRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgrn1 NCBI NCBI:23295