Atp6ap1 - ATPase, H+ transporting, lysosomal accessory protein 1 Gene

Also Known as 16A; CF2; AC45; C7-1; XAP-3; Atp6s1; VATPS1; Atp6ip1; mFLJ00383

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54411

Summary

Enables small GTPase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of bone resorption; and positive regulation of cell differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in integumental system; nervous system; sensory organ; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp6ap1 Products (3)

mRNA Protein Name
NM_001358375.1 NP_001345304.1 V-type proton ATPase subunit S1 isoform 2 precursor
NM_001358380.1 NP_001345309.1 V-type proton ATPase subunit S1 isoform 3 precursor
NM_018794.4 NP_061264.1 V-type proton ATPase subunit S1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATPase activator activity IMP
IMP: Inferred from mutant phenotype
22087256 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
22467241 MGI
enables transporter activator activity IMP
IMP: Inferred from mutant phenotype
22087256 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in endosome to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
22467241 MGI
involved in osteoclast development IMP
IMP: Inferred from mutant phenotype
22467241 MGI
NOT involved in proton-transporting V-type ATPase complex assembly IMP
IMP: Inferred from mutant phenotype
22467241 MGI
involved in synaptic vesicle lumen acidification EXP
EXP: Inferred from Experiment
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: Inferred from direct assay
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
28793259 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in endosome membrane IMP
IMP: Inferred from mutant phenotype
22087256 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type proton ATPase subunit S1

  • ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1

  • ATPase, H+ transporting, lysosomal interacting protein 1

  • V-ATPase Ac45 subunit

  • V-ATPase S1 accessory protein

  • V-ATPase subunit Ac45

  • V-ATPase subunit S1

  • protein C7-1

  • vacuolar H+ ATP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01214 ATP6AP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp6ap1 NCBI NCBI:537