DNAJB9 - DnaJ heat shock protein family (Hsp40) member B9 Gene

Also Known as MDG1; ERdj4; MDG-1; MST049; MSTP049

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4189

About DNAJB9

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:108,569,874-108,574,850 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 55.6), adrenal (RPKM 35.9) and 25 other tissues.

Summary

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from Apoptosis. [provided by RefSeq, Dec 2010]

DNAJB9 Products (1)

mRNA Protein Name
NM_012328.3 NP_036460.1 dnaJ homolog subfamily B member 9 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables misfolded protein binding IDA
IDA: Inferred from direct assay
18400946 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19815549 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
18400946 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB9 Protein Structure

DnaJ

DnaJ: DnaJ domain (27 - 87)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 9

  • DnaJ (Hsp40) homolog, subfamily B, member 9

DNAJB9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAJB9 Q9UBS3 HSPA5 Homo sapiens P11021
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunoglobulin Heavy Chain Amyloidosis

  • Ah Amyloidosis

  • Heavy Chain Amyloidosis

  • Amyloidosis Derived From Immunoglobulin Heavy Chain

  • Ig Heavy-Chain-Associated Amyloidosis
Gestational Ovarian Choriocarcinoma
Non-Gestational Choriocarcinoma

  • Choriocarcinoma, Non-Gestational
Non-Gestational Ovarian Choriocarcinoma
Choriocarcinoma Of Ovary

  • Ovarian Choriocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03871 DNAJB9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DNAJB9 VGNC VGNC:108396
Felis catus DNAJB9 VGNC VGNC:80595
Rattus norvegicus DNAJB9 RGD RGD:3070
Canis familiaris DNAJB9 VGNC VGNC:53539
Mus musculus DNAJB9 MGD MGI:1351618