Trem2 - triggering receptor expressed on myeloid cells 2 Gene

Also Known as TREM-2; Trem2a; Trem2b; Trem2c

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83433

Summary

The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and Phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Trem2 Products (2)

mRNA	Protein	Name
NM_001272078.1	NP_001259007.1	triggering receptor expressed on myeloid cells 2 isoform 2 precursor
NM_031254.3	NP_112544.1	triggering receptor expressed on myeloid cells 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	12847223	MGI
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	12847223	MGI
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	12847223	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16715077	MGI
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	29518356	MGI
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	16715077	MGI
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	16715077	MGI
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	29518356	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	16715077	MGI
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	29859094	MGI
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	30617257	MGI
involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15728241	MGI
involved in astrocyte activation	IGI IGI: Inferred from genetic interaction	29073081	MGI
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	29518356	MGI
involved in cellular response to lipoteichoic acid	IDA IDA: Inferred from direct assay	12847223	MGI
involved in cellular response to peptidoglycan	IDA IDA: Inferred from direct assay	12847223	MGI
involved in complement-mediated synapse pruning	IMP IMP: Inferred from mutant phenotype	30548312	MGI
acts upstream of or within positive effect defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	29887864	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	30232263	MGI
involved in dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	31980586	MGI
involved in detection of lipopolysaccharide	IDA IDA: Inferred from direct assay	12847223	MGI
involved in detection of lipoteichoic acid	IDA IDA: Inferred from direct assay	12847223	MGI
involved in detection of peptidoglycan	IDA IDA: Inferred from direct assay	12847223	MGI
involved in excitatory synapse pruning	IMP IMP: Inferred from mutant phenotype	29752066	MGI
involved in import into cell	IGI IGI: Inferred from genetic interaction	29073081	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	31257031	MGI
involved in microglial cell activation	IGI IGI: Inferred from genetic interaction	29073081	MGI
involved in microglial cell activation	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in microglial cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	30232263	MGI
involved in microglial cell proliferation	IMP IMP: Inferred from mutant phenotype	25631124	MGI
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	29887864	MGI
involved in negative regulation of amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	30617257	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in negative regulation of astrocyte activation	IDA IDA: Inferred from direct assay	29407460	MGI
involved in negative regulation of autophagic cell death	IGI IGI: Inferred from genetic interaction	28802038	MGI
involved in negative regulation of autophagy	IGI IGI: Inferred from genetic interaction	28802038	MGI
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	28802038	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in negative regulation of cell activation	IDA IDA: Inferred from direct assay	29407460	MGI
involved in negative regulation of cholesterol storage	IMP IMP: Inferred from mutant phenotype	31902528	MGI
involved in negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	29887864	MGI
involved in negative regulation of fat cell proliferation	IMP IMP: Inferred from mutant phenotype	31257031	MGI
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in negative regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in negative regulation of neuroinflammatory response	IDA IDA: Inferred from direct assay	29407460	MGI
involved in negative regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	31134514	MGI
involved in negative regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	31900229	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in negative regulation of sequestering of triglyceride	IMP IMP: Inferred from mutant phenotype	31902528	MGI
involved in negative regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	31134514	MGI
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	29407460	MGI
involved in negative regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	31134514	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	29859094	MGI
acts upstream of or within phagocytosis, engulfment	IDA IDA: Inferred from direct assay	19155473	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	24990881	MGI
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	28802038	MGI
involved in positive regulation of CAMKK-AMPK signaling cascade	IGI IGI: Inferred from genetic interaction	28802038	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in positive regulation of TOR signaling	IGI IGI: Inferred from genetic interaction	28802038	MGI
involved in positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	26949937	MGI
involved in positive regulation of chemotaxis	IGI IGI: Inferred from genetic interaction	28483841	MGI
involved in positive regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	31902528	MGI
involved in positive regulation of complement activation, classical pathway	IMP IMP: Inferred from mutant phenotype	30548312	MGI
involved in positive regulation of establishment of protein localization	IMP IMP: Inferred from mutant phenotype	30617257	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	29073081	MGI
involved in positive regulation of high-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	31257031	MGI
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in positive regulation of inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	29518356	MGI
involved in positive regulation of low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	31257031	MGI
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	18957693	MGI
involved in positive regulation of microglial cell activation	IDA IDA: Inferred from direct assay	31370707	MGI
involved in positive regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	24990881	MGI
involved in positive regulation of microglial cell migration	IGI IGI: Inferred from genetic interaction	28483841	MGI
involved in positive regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	28483841	MGI
involved in positive regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	25631124	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	16418779	MGI
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	25631124	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30684126	MGI
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	29518356	MGI
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	29518356	MGI
acts upstream of or within negative effect pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	29887864	MGI
involved in regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	28802038	MGI
involved in regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	29663649	MGI
involved in regulation of gene expression	IGI IGI: Inferred from genetic interaction	29518356	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	30548312	MGI
involved in regulation of hippocampal neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	30684126	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	30548312	MGI
involved in regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	29518356	MGI
involved in regulation of intracellular signal transduction	IGI IGI: Inferred from genetic interaction	29518356	MGI
involved in regulation of macrophage inflammatory protein 1 alpha production	IGI IGI: Inferred from genetic interaction	29518356	MGI
involved in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	30684126	MGI
involved in regulation of peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	29518356	MGI
involved in regulation of plasma membrane bounded cell projection organization	IMP IMP: Inferred from mutant phenotype	28483841	MGI
involved in regulation of resting membrane potential	IMP IMP: Inferred from mutant phenotype	29518356	MGI
involved in regulation of toll-like receptor 6 signaling pathway	IMP IMP: Inferred from mutant phenotype	31134514	MGI
involved in respiratory burst after phagocytosis	IMP IMP: Inferred from mutant phenotype	30548312	MGI
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	31235932	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	28592261	MGI
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	16715077	MGI
acts upstream of positive effect social behavior	IMP IMP: Inferred from mutant phenotype	29752066	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28855301	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24990881	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
triggering receptor expressed on myeloid cells 2	triggering receptor expressed on monocytes 2 triggering receptor expressed on myeloid cells 2a triggering receptor expressed on myeloid cells 2b triggering receptor expressed on myeloid cells 2c

Trem2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Trem2	Q99NH8	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	ELISA	30341064

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Trem2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71381	TREM-2 Protein, Mouse (HEK293, His)	Q99NH8-1 (L19-P168)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10227	Bortezomib		99.97%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W017540	Cyclocreatine	Activator	99.78%	Phase 1

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990043	Iluzanebart		98.63%	Phase 2
HY-P991734	VHB937		99.9%	Phase 2
HY-P990651	PY314	Inhibitor	96.35%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10136	IA9	Inhibitor	97.24%	Unkown
HY-160421	TREM2-IN-1	Inducer	99.34%	Unkown
HY-175510	TREM2 agonist-5	Agonist	99.61%	Unkown
HY-P10136A	IA9 TFA	Inhibitor	98.90%	Unkown
HY-174369	TREM2 agonist-3		99.39%	Unkown
HY-174378	TREM2 agonist-4	Inhibitor	99.81%	Unkown
HY-182702	As48		/	Unkown
HY-P991754	Anti-Mouse TREM2 Antibody (178)	Inhibitor	98.92%	Unkown
HY-RS16526	Trem2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10227S	Bortezomib-d8		98.0%	Unkown
HY-169859	EP4 receptor antagonist 7	Antagonist	99.9%	Unkown
HY-178324	T2M-010		/	Unkown
HY-RS15003	TREM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182756	TREM2 modulator-1	Modulator	/	Unkown
HY-10227G	Bortezomib (GMP)		/	Unkown
HY-P10220	NOTA-COG1410	Ligand	/	Unkown
HY-W017540S	Cyclocreatine-13C3		/	Unkown
HY-N9164	Hecubine		/	Unkown
HY-RS22957	Trem2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991220	AL002	Agonist	98.01%	Unkown
HY-P991621	EOS006215	Inhibitor	98.47%	Unkown
HY-P991442	DNL-919 (Human IgG1)	Agonist	96.17%	Unkown
HY-P991174	Anti-TREM2 Antibody (AL2p-58)	Inhibitor	97.43%	Unkown
HY-P992118	Lifonebart	Inhibitor	99.9%	Unkown
HY-P992513	Anti-Mouse TREM2 Antibody (4D9)	Inhibitor	/	Unkown
HY-P991905	AL044		97.39%	Unkown
HY-P992516	DNL-919 (ATV)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trem2	NCBI	NCBI:54209