46 Results for "

DISC

" in MedChemExpress (MCE) Product Catalog:
Products (46)

46 Results for "DISC" in MCE Product Catalog:

15
DiSC3(5)
DiSC3(5)
0 Images
15 Cited Publications
Cat. No.: HY-D0085
CAS No.: 53213-94-8
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3(5) in the presence of Na +/K +-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .
4
DC-Y13-27
DC-Y13-27
0 Images
4 Cited Publications
Cat. No.: HY-154919
Purity:  99.52%
Target:  

YTHDF FOXO MMP Pyroptosis Interleukin Related

Research Areas:  

Endocrinology Cancer

DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (KD: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .
4
Kinsenoside
Kinsenoside
0 Images
4 Cited Publications
Cat. No.: HY-N2292
CAS No.: 151870-74-5
Category:  

Natural Products Orchidaceae Plants Anoectochilus Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).
1
Procyanidin B3
Procyanidin B3
0 Images
1 Cited Publications
Cat. No.: HY-N2345
CAS No.: 23567-23-9
Category:  

other families Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Plants Disease Research Fields Biflavones Cancer

Target:  

Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor

Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .
1
NSC45586 sodium
NSC45586 sodium
0 Images
1 Cited Publications
Cat. No.: HY-19820A
CAS No.: 6300-44-3
Target:  

Akt Ser/Thr Protease Apoptosis MMP

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

NSC45586 sodium is an inhibitor of PHLPP. NSC45586 sodium targets the PP2C phosphatase domains of PHLPP1 and PHLPP2, blocks the phosphatase activity of PHLPP, increases the expression level of FOXO1 in the nucleus, and reduces the protein expression of PHLPP1. NSC45586 sodium activates the AKT survival signaling pathway, enhances IGF-1-induced AKT activation, and inhibits the phosphorylation of AKT/ERK under basal conditions. NSC45586 sodium reduces staurosporine-induced neuronal death, preserves notochord cell morphology and KRT19 expression, inhibits cell apoptosis (apoptosis), improves the viability and proliferation of nucleus pulposus cells, upregulates the expression of ACAN/SOX9, and downregulates the expression of MMP13. NSC45586 sodium binds tightly to bovine serum albumin (bovine serum albumin), and exerts a more significant effect on nucleus pulposus in male individuals. NSC45586 sodium can be used in studies related to global cerebral ischemia and intervertebral disc degeneration .
1
Diacetoxy-6-gingerdiol
Diacetoxy-6-gingerdiol
0 Images
1 Cited Publications
Cat. No.: HY-133865
CAS No.: 143615-75-2
Purity:  98.01%
Category:  

Zingiber officinale Roscoe Monophenols Other Diseases Phenols Plants Disease Research Fields Zingiberaceae

Target:  

Interleukin Related

Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .
1
Physalin A
Physalin A
0 Images
1 Cited Publications
Cat. No.: HY-N9942
CAS No.: 23027-91-0
Category:  

Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Ketones, Aldehydes, Acids Plants Solanaceae Disease Research Fields Cancer

Target:  

Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK

Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .
Murine Thrombin
Murine Thrombin
0 Images
Cat. No.: HY-114164G
CAS No.: 9002-04-4
Target:  

Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus .
Mivacurium dichloride
Mivacurium dichloride
0 Images
Cat. No.: HY-B1700A
CAS No.: 106861-44-3
Target:  

nAChR

Research Areas:  

Neurological Disease

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .
GSK1995057
GSK1995057
0 Images
Cat. No.: HY-P991400

Target:  

TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK

Research Areas:  

Inflammation/Immunology

GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .
Link N peptide
Link N peptide
0 Images
Cat. No.: HY-P10954
CAS No.: 197295-74-2
Target:  

p38 MAPK

Research Areas:  

Others

Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .
Vicatertide
Vicatertide
0 Images
Cat. No.: HY-P5542
CAS No.: 1251838-01-3
Synonyms: SB-01; Peniel 2000
Target:  

Factor Xa TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a Ka of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases .
DiSC3(5) (solution)
DiSC3(5) (solution)
0 Images
Cat. No.: HY-DY1021
CAS No.: 53213-94-8
DiSC3 (5) (solution) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3 (5) in the presence of Na +/K +-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .
Solvent and concentration: DMSO: 1 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
TBE56
TBE56
0 Images
Cat. No.: HY-17655
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology

TBE56, a molecular glue, is a BACH1 degrader, with an EC50 of 44 nM. TBE56 is a weak NRF2 inducer and the biotinylated TBE31. TBE56 interacts and promotes the degradation of BACH1 via a mechanism involving the E3 ligase FBX022. TBE56 reduces intracellular Fe 2+ accumulation, ROS generation, and malondialdehyde (MDA) content, while increasing GSH/GSSG ratio and upregulating GPX4 in Prominin-2-overexpressed BMSCs. TBE56 significantly ameliorates intervertebral disc degeneration (IVDD) in puncture-induced SD rat IVDD model. TBE56 can be used for the study of intervertebral disc degeneration (IVDD) .
Methyl 4-hydroxyphenylacetate
Methyl 4-hydroxyphenylacetate
0 Images
Cat. No.: HY-W001084
CAS No.: 14199-15-6
Category:  

Microorganisms Monophenols Other Diseases Phenols Disease Research Fields

Target:  

Others

Methyl 4-hydroxyphenylacetate is a compound found in the marine fungus Penicillium oxalicum 0312F1. Methyl 4-hydroxyphenylacetate can be Methyl 4-hydroxyphenylacetate inhibits replication of tobacco mosaic virus (TMV) in Nicotiana tabacum leaf discs. Methyl 4-hydroxyphenylacetate shows inhibitory activity against proliferation of cancer cells. Methyl 4-hydroxyphenylacetate can be used for the researches of TMV infection and cancer .
Ningnanmycin
Ningnanmycin
0 Images
Cat. No.: HY-N13047
CAS No.: 156410-09-2
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

TMV SOD

Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection .
Velutin
Velutin
0 Images
Cat. No.: HY-N1098
CAS No.: 25739-41-7
Category:  

other families Flavonoids Microorganisms Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase p38 MAPK NF-κB Bacterial

Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC50 of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .
Plipastatin A1
Plipastatin A1
0 Images
Cat. No.: HY-P10447
CAS No.: 103651-09-8
Synonyms: Fengycin IX; SNA-60-367-3
Target:  

Phospholipase Fungal

Research Areas:  

Infection

Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold [1][2].
Chymopapain
Chymopapain
0 Images
Cat. No.: HY-108909
CAS No.: 9001-09-6
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain has neurotoxicity when injected into nerve bundles. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .
Anti-IL-15 Antibody (DISC0280)
Anti-IL-15 Antibody (DISC0280)
0 Images
Cat. No.: HY-P990446
Synonyms: DISC0280

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

The Anti-IL-15 Antibody (DISC0280) is a CHO-expressed human antibody that targets IL-15. The Anti-IL-15 Antibody (DISC0280) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-IL-15 Antibody (DISC0280) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
Assay Types