1251838-01-3
Chemical Structure
Vicatertide
Synonym(s): SB-01; Peniel 2000
- CAS No.: 1251838-01-3
- Formula:C42H66N10O10
- Molecular Weight:871.03
InChIKey: MLCMYVUVOHSNFD-WVMYFBOZSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O
Biological Activity: Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a Ka of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vicatertide | 99.24% | Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a Ka of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases. | ||||||||||||||||||||
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- [1]. Sharma C, et al. Discovery and preclinical characterization of SB-01, a novel allosteric inhibitor of human factor XIa. Blood, 2025, 146 (Supplement 1): 16.
- [2]. Kwon YJ, et al. Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration. Spine (Phila Pa 1976). 2013;38(2):E49-E58. [Content Brief]
Keywords
