156410-09-2
Chemical Structure
Ningnanmycin
- CAS 番号: 156410-09-2
- Formula:C16H25N7O8
- Molecular Weight:443.41
InChIKey: AMNAZJFEONUVTD-KEWDHRJRSA-N
SMILES: O[C@H]1[C@H](N2C(N=C(C=C2)N)=O)O[C@@H]([C@H]([C@@H]1O)NC([C@H](CO)NC(CNC)=O)=O)C(N)=O
Biological Activity: Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection[1][2].
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Ningnanmycin | Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection. | |||||||||||||||||||||
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- [1]. Li X, et al. Ningnanmycin inhibits tobacco mosaic virus virulence by binding directly to its coat protein discs. Oncotarget. 2017;8(47):82446-82458. Published 2017 Jul 19. [Content Brief]
- [2]. Wu Z, et al. Ningnanmycin Activates Defense Systems against Potato Virus Y in Nicotiana benthamiana. J Agric Food Chem. 2024 Dec 4;72(48):26633-26643. [Content Brief]
Keywords
