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Referencia número: HY-146420

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GRP78-IN-2

GRP78-IN-2 (Compound FL5) is a GRP78 (Glucose Regulated Protein 78 kDa) inhibitor. GRP78-IN-2 preferentially targeting cell surface GRP78 and shows potent antiangiogenic and anticancer activities without affecting other normal cells.

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No. CAS: 1882875-63-9
Fòrmula: C₂₉H₂₉NO₆
Peso molecular:487.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

GRP78-IN-2 Chemical Structure

No. CAS: 1882875-63-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Grp78

Ver todos los productos específicos de isoformas HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	CC₅₀	10 μM Compound: FL5	Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay	[PMID: 32199134]
HUVEC	CC₅₀	10 μM Compound: FL5	Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32199134]
HUVEC	EC₅₀	1.514 μM Compound: FL5	Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32199134]

Chemical Information

No. CAS 1882875-63-9
Peso molecular 487.54
Fòrmula C₂₉H₂₉NO₆
SMILES

COC1=CC(OC)=CC(C(OCC2=CC=C(C=C2)C3=C(C4=CC=CC=C4O3)C(NCC(C)C)=O)=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Qiao Y, et al. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. Eur J Med Chem. 2020 May 1;193:112228. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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GRP78-IN-2

Ver todos los productos específicos de isoformas HSP

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

GRP78-IN-2 Related Classifications

HY-146420 Related Classifications