JAK1-IN-18
JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 of 0.15 nM for JAK1 over JAK2 and JAK3. JAK1-IN-18 significantly reduces inflammation in DSS (HY-116282C)-induced ulcerative colitis (UC) mouse models and DNBS(HY-W324435)-induced Crohn's disease (CD) rat models. JAK1-IN-18 can be used for autoimmune diseases (such as inflammatory bowel disease), viral infections (such as HBV infection) and cancers (such as blood cancer) research.
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- No. CAS: 2459377-98-9
- Fòrmula: C16H20F2N6O2
- Peso molecular:366.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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JAK1 0.15 nM (IC50) |
JAK2 3.69 nM (IC50) |
JAK3 3.10 nM (IC50) |
Tyk2 1.49 nM (IC50) |
Chemical Information
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No. CAS 2459377-98-9
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Peso molecular 366.37
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Fòrmula C16H20F2N6O2
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SMILES
O=C(NCC(F)F)[C@@H]1CN(CCC1)NC2=C3C(NC=C3)=NC=C2C(N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK1-IN-18 Related Classifications
HY-176793 Related Classifications
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