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Cat. No.: HY-184662

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Ferroptosis inducer-17

Ferroptosis inducer-17 is a ferroptosis inducer that downregulates GPX4 and activates the CTSB and cGAS-STING pathways. Ferroptosis inducer-17 exhibits cytotoxicity against cancer cells but low toxicity toward normal cells. Ferroptosis inducer-17 accumulates in mitochondria and lysosomes, thereby inducing ROS production, lipid peroxidation, mitochondrial membrane depolarization, lysosomal iron accumulation, increased membrane permeability, and enhanced oxidative stress. Ferroptosis inducer-17 inhibits tumor growth in cisplatin-resistant xenograft models. Ferroptosis inducer-17 can be used for cancer-related research.

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화학식: C₃₇H₄₁N₃O₇Zr
분자량:730.96

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ferroptosis inducer-17 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

GPX4	Cathepsin B

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

All Cathepsin Isoforms :

In Vitro

Anti-cancerCell Cycle RegulationEMT / MetastasisFerroptosisApoptosisCytokines &ChemokinesMitochondrial FunctionLysosomal MetabolismOxidative Stress

Anti-cancer

Cell Cycle Regulation

Ferroptosis inducer-17 (4 μM) induces G1-phase cell cycle arrest in Hep G2/DDP cells^[1].

Anti-cancer

EMT / Metastasis

Ferroptosis inducer-17 (compound 1t) (4 μM; 24 h, 48 h) potently inhibits migration of Hep G2/DDP cells after 24 h and 48 h of incubation^[1].

Anti-cancer

Ferroptosis

Ferroptosis inducer-17 (4 μM; 12 h) downregulates GPX4 protein expression in Hep G2/DDP cells^[1].
Ferroptosis inducer-17 (4 μM; 24 h) increases lysosomal iron^II levels and lysosomal pH in Hep G2/DDP cells^[1].
Ferroptosis inducer-17 (4 μM; 24 h) upregulates NCOA4 and SLC7A11 protein expression in Hep G2/DDP cells^[1].
Ferroptosis inducer-17 (compound 1t) (4 μM; 0.1-48 h) accumulates continuously in Hep G2/DDP cells over 48 h, reaching a maximum Zr content of 22.50 ng^[1].
Ferroptosis inducer-17 (compound 1t) (range of concentrations; 48 h) potently inhibits proliferation of Hep G2, Hep G2/DDP, SW620/DDP, and HeLa S3 cancer cells with IC₅₀ values of 3.9 μM, 2.3 μM, 13.9 μM, and 51.8 μM respectively, while sparing normal LO2 liver cells^[1].

Anti-cancer

Ferroptosis

Apoptosis

Ferroptosis inducer-17 (4 μM; 24 h) induces ferroptosis as the predominant mode of cell death in Hep G2/DDP cells, with a minor contribution from apoptosis^[1].

Anti-cancer

Ferroptosis

Cytokines &

Chemokines

Ferroptosis inducer-17 (4 μM; 24 h) modulates the expression of IFN-α, IFN-β, IFN-γ, IL-6, cGAS, and STING in Hep G2/DDP cells^[1].

Anti-cancer

Ferroptosis

Mitochondrial Function

Lysosomal Metabolism

Ferroptosis inducer-17 (4 μM; 24 h) preferentially localizes to mitochondria and lysosomes in Hep G2/DDP cells after 24 h of incubation^[1].

Anti-cancer

Ferroptosis

Oxidative Stress

Ferroptosis inducer-17 (4 μM) disrupts redox homeostasis in Hep G2/DDP cells and promotes membrane damage associated with lipid peroxidation; also increases ROS levels in Hep G2/DDP cells; causes mitochondrial membrane depolarization in Hep G2/DDP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

Hep G2/DDP (cisplatin-resistant hepatocellular carcinoma)
Concentration:

4 μM
Incubation Time:

24 h, 48 h
Result:

Markedly inhibited Hep G2/DDP cell migration, reducing wound closure rates from 26.42% (control) to 1.73% at 24 h.
Markedly inhibited Hep G2/DDP cell migration, reducing wound closure rates from 40.88% (control) to 7.87% at 48 h.

Cell Viability Assay^[1]

Cell Line:

Hep G2/DDP (cisplatin-resistant hepatocellular carcinoma)
Concentration:

4 μM; 10 μM (Ferrostatin-1, 3-MA), 20 μM (Z-VAD-FMK)
Incubation Time:

24 h (Ferroptosis inducer-17); 1 h (inhibitors pretreatment)
Result:

Only Ferrostatin-1 (HY-100579) (ferroptosis inhibitor) and Z-VAD-FMK (HY-16658B) (apoptosis inhibitor) substantially rescued cell viability, with Ferrostatin-1 showing the most significant rescue effect.

Western Blot Analysis^[1]

Cell Line:

Hep G2/DDP (cisplatin-resistant hepatocellular carcinoma)
Concentration:

4 μM
Incubation Time:

12 h
Result:

Markedly reduced GPX4 protein expression levels compared to untreated control cells.

Western Blot Analysis^[1]

Cell Line:

Hep G2/DDP (cisplatin-resistant hepatocellular carcinoma)
Concentration:

4 μM
Incubation Time:

24 h
Result:

Markedly increased NCOA4 protein expression levels compared to untreated control cells.
Markedly increased SLC7A11 protein expression levels compared to untreated control cells.

Real Time qPCR^[1]

Cell Line:

Hep G2/DDP (cisplatin-resistant hepatocellular carcinoma)
Concentration:

4 μM
Incubation Time:

24 h
Result:

Modulated the expression of IFN-α, IFN-β, IFN-γ, IL-6, cGAS, and STING.

In Vivo

Anti-cancerFerroptosis

Anti-cancer

Ferroptosis

Ferroptosis inducer-17 (compound 1t) (2.9 mg/kg; i.v.; single dose) significantly suppresses tumor growth in cisplatin-resistant hepatocellular carcinoma orthotopic xenografts with minimal systemic toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID (male, 5-6 weeks old)^[1]
Dosage:

2.9 mg/kg
Administration:

i.v.; single dose
Result:

Significantly suppressed tumor growth in the cisplatin-resistant Hep G2/DDP orthotopic xenograft model.
Showed minimal systemic toxicity.

Related Protocols :

Chemical Information

분자량 730.96
화학식 C₃₇H₄₁N₃O₇Zr
SMILES

CC1=CC(C(C)(C)C)=C2O[Zr]34(OC5=O)(OC(C6=CC(O)=CC5=N6)=O)OC7=C(C(C)(C)C)C=C(C)C=C7C[N]3(CC8=CC=CC=[N]84)CC2=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhao T, et al. GPX4-Targeting Phenolato Zr Complexes Induce Ferroptosis and Lysosome-Dependent Cell Death for Immunotherapy of Chemoresistant Cancer. Journal of medicinal chemistry. 2026 Jun 25. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Ferroptosis inducer-17

All Glutathione Peroxidase Isoforms

All Cathepsin Isoforms