Hsp90-IN-15
Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell.
For research use only. We do not sell to patients.
- CAS No.: 2252283-32-0
- Formula: C23H27F3N4
- Molecular Weight:416.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
19.6 μM
Compound: 22g
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 31928863] |
| HepG2 | IC50 |
16.1 μM
Compound: 22g
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 31928863] |
| MDA-MB-231 | IC50 |
22.1 μM
Compound: 22g
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 31928863] |
Hsp90-IN-15 (compound 22g) againsts HeLa, HepG2, and MDA-MB-23 cells with IC50s of 19.6 μM, 16.1 μM, and 22.1 μM, respectively[1].
Hsp90-IN-15 binds with Hsp90N, and the △Tm value is 10.92 °C[1].
Hsp90-IN-15 (0-20 μM; 48 h) arrests cell cycle at S phase in a dose-dependent manner[1].
Hsp90-IN-15 (0-20 μM; 48 h) exhibits an accumulation of early and late apoptotic cells in a time and dose dependent manner[1].
Caspase-3 is an executioner caspase and modifies apoptosis proteins[1].
Hsp90-IN-15 (0-50 μM; 48 h) increases the expression of Bax and cleaved-caspase 3, as well as downregulates the levels of Bcl-2, pro-caspase 3 and Hsp90[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:48 hours
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Result:Arrested cell cycle at S phase dose-dependently.
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Cell Line:HeLa cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:48 hours
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Result:Induced apoptosis in HeLa cells.
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Cell Line:HeLa cells
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Concentration:0, 12.5, 25, 50 μM
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Incubation Time:48 hours
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Result:Decreased the level of Hsp90 and increased the proportion of Bax/Bcl-2 as well.
Chemical Information
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CAS No. 2252283-32-0
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Molecular Weight 416.48
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Formula C23H27F3N4
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SMILES
[H][C@@]12CCCN3CCC[C@@]([C@@]31[H])([C@]4(CCC5=C(C6=C(N=C5N4C2)C=CC(C(F)(F)F)=C6)N)[H])[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hsp90-IN-15 Related Classifications
HY-150655 Related Classifications
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