Vigabatrin hydrochloride
Based on 6 publication(s) in Google Scholar
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1391054-02-6
- Formula: C6H12ClNO2
- Molecular Weight:165.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Vigabatrin hydrochloride
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ELISA
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ELISA
Biological Activity
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1391054-02-6
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Appearance Solid
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Molecular Weight 165.62
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Formula C6H12ClNO2
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Color White to off-white
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SMILES
C=CC(N)CCC(O)=O.Cl
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Synonyms
γ-Vinyl-GABA hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Redox Biol
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]2021 Oct:46:102082. PMID: 34343908 -
Cell Rep
2022 Dec 6;41(10):111770. PMID: 36476877
Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on FAD production in M0 macrophages.
Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on inflammasome activation in M1 macrophages.
Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on mitochondrial functions in M1 macrophages.
Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) rescued the effects of GABA on IL-1β productionin in M1 macrophages.
Vigabatrin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 6;41(10):111770. [Abstract]
Vigabatrin (100 mg/kg) promoted IL-1β production in macrophages without GABA treatment.
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J Exp Bot
2020 Feb 19;71(4):1459-1474. PMID: 31740934 -
Plants
Effects of GABA and Vigabatrin on the Germination of Chinese Chestnut Recalcitrant Seeds and Its Implications for Seed Dormancy and Storage. [Abstract]2020 Apr 3;9(4):449. PMID: 32260136 -
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Animals (Basel)
2020 Mar 27;10(4):567. PMID: 32230949
Solvent & Solubility
H2O : 33.33 mg/mL (201.24 mM; Need ultrasonic)
DMSO : 27.5 mg/mL (166.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (60.38 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [Content Brief]
[2]. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. [Content Brief]
[3]. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.0379 mL | 30.1896 mL | 60.3792 mL | 150.9480 mL |
| 5 mM | 1.2076 mL | 6.0379 mL | 12.0758 mL | 30.1896 mL | |
| 10 mM | 0.6038 mL | 3.0190 mL | 6.0379 mL | 15.0948 mL | |
| 15 mM | 0.4025 mL | 2.0126 mL | 4.0253 mL | 10.0632 mL | |
| 20 mM | 0.3019 mL | 1.5095 mL | 3.0190 mL | 7.5474 mL | |
| 25 mM | 0.2415 mL | 1.2076 mL | 2.4152 mL | 6.0379 mL | |
| 30 mM | 0.2013 mL | 1.0063 mL | 2.0126 mL | 5.0316 mL | |
| 40 mM | 0.1509 mL | 0.7547 mL | 1.5095 mL | 3.7737 mL | |
| 50 mM | 0.1208 mL | 0.6038 mL | 1.2076 mL | 3.0190 mL | |
| 60 mM | 0.1006 mL | 0.5032 mL | 1.0063 mL | 2.5158 mL | |
| 80 mM | 0.0755 mL | 0.3774 mL | 0.7547 mL | 1.8868 mL | |
| 100 mM | 0.0604 mL | 0.3019 mL | 0.6038 mL | 1.5095 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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