Arsthinenol
Arsthinenol (Arsthinol; Balarsen) is an orally active small organic arsenic molecule. Arsthinenol exhibits anti-amoebic activity by eliminating cysts and trophozoites of Entamoeba histolytica in feces and promoting the healing of amoebic rectal ulcers. Arsthinenol forms the hydroxypropyl-β-cyclodextrin inclusion complex STB-HPβCD, which has an IC50 of 31.6 μM against U87 MG cells and possesses anti-tumor activity. Arsthinenol can be used in the research of intestinal amoebiasis and glioblastoma.
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- No. CAS: 119-96-0
- Fòrmula: C11H14AsNO3S2
- Peso molecular:347.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Arsthinenol (STB) forms 1:1 inclusion complexes with HPβCD and RAMEβCD, with high apparent stability constants measured via phase solubility studies at 25 °C[2].
Arsthinenol (0.01 μM, 1 mM; 24-48 h) and its HPβCD complex exhibit dose- and time-dependent cytotoxicity against U87 MG glioma cells, with Arsthinol showing a significantly higher therapeutic index than reference arsenical compounds after 48 h incubation, reaching an IC50 of 2.8 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 119-96-0
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Peso molecular 347.29
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Fòrmula C11H14AsNO3S2
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SMILES
CC(NC1=CC([As]2SCC(CO)S2)=CC=C1O)=O
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Synonyms
Arsthinol; Balarsen
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. BROWN CH, et al. Intestinal amebiasis; incidence, symptoms, and treatment with arsthinol (balarsen). J Am Med Assoc. 1956 Feb 4;160(5):360-3. [Content Brief]
[2]. Becherirat S, et al. The antitumor effects of an arsthinol-cyclodextrin complex in a heterotopic mouse model of glioma. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):560-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arsthinenol Related Classifications
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