119-96-0
Chemical Structure
Arsthinenol
Synonym(s): Arsthinol; Balarsen
- CAS No.: 119-96-0
- Formula:C11H14AsNO3S2
- Molecular Weight:347.29
IUPAC Name: N-(2-hydroxy-5-(4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl)phenyl)acetamide
InChIKey: MRUDSZSRLQAPOG-UHFFFAOYSA-N
SMILES: CC(NC1=CC([As]2SCC(CO)S2)=CC=C1O)=O
Biological Activity: Arsthinenol (Arsthinol; Balarsen) is an orally active small organic arsenic molecule. Arsthinenol exhibits anti-amoebic activity by eliminating cysts and trophozoites of Entamoeba histolytica in feces and promoting the healing of amoebic rectal ulcers. Arsthinenol forms the hydroxypropyl-β-cyclodextrin inclusion complex STB-HPβCD, which has an IC50 of 31.6 μM against U87 MG cells and possesses anti-tumor activity. Arsthinenol can be used in the research of intestinal amoebiasis and glioblastoma[1][2].
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Arsthinenol | Arsthinenol (Arsthinol; Balarsen) is an orally active small organic arsenic molecule. Arsthinenol exhibits anti-amoebic activity by eliminating cysts and trophozoites of Entamoeba histolytica in feces and promoting the healing of amoebic rectal ulcers. Arsthinenol forms the hydroxypropyl-β-cyclodextrin inclusion complex STB-HPβCD, which has an IC50 of 31.6 μM against U87 MG cells and possesses anti-tumor activity. Arsthinenol can be used in the research of intestinal amoebiasis and glioblastoma. | |||||||||||||||||||||
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References
- [1]. BROWN CH, et al. Intestinal amebiasis; incidence, symptoms, and treatment with arsthinol (balarsen). J Am Med Assoc. 1956 Feb 4;160(5):360-3. [Content Brief]
- [2]. Becherirat S, et al. The antitumor effects of an arsthinol-cyclodextrin complex in a heterotopic mouse model of glioma. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):560-8. [Content Brief]
