SCARB2 - scavenger receptor class B member 2 Gene

Also Known as AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 950

About SCARB2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,158,737-76,234,532 (from NCBI)

This gene has 28 transcripts (splice variants), 216 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 74.6), prostate (RPKM 71.6) and 25 other tissues.

Summary

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

SCARB2 Products (2)

mRNA	Protein	Name
NM_001204255.2	NP_001191184.1	lysosome membrane protein 2 isoform 2 precursor
NM_005506.4	NP_005497.1	lysosome membrane protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Referencias	Source
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	18022370	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	18022370	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24162852	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	29199275	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	18022370	GOA
involved in regulation of carbohydrate catabolic process	IMP IMP: Inferred from mutant phenotype	18022370	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCARB2 Protein Structure

CD36

0
100
200
300
400
478 a.a.

Protein Preferred Names	Protein Names
lysosome membrane protein 2	85 kDa lysosomal membrane sialoglycoprotein

SCARB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SCARB2	Q14108	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	SCARB2	Q14108	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	SCARB2	Q14108	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	SCARB2	Q14108	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SCARB2	Q14108	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SCARB2	Q14108	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	SCARB2	Q14108	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	SCARB2	Q14108	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	SCARB2	Q14108	LAPTM4B	Homo sapiens	Q86VI4	Validated Y2H	32296183
Intra	SCARB2	Q14108	LAPTM4B	Homo sapiens	Q86VI4	Y2H Array	32296183
Intra	SCARB2	Q14108	LAPTM4B	Homo sapiens	Q86VI4	Y2H Prey Pooling	32296183
Intra	SCARB2	Q14108	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SCARB2	Q14108	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SCARB2	Q14108	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCARB2 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P71278	SCARB2/LIMP-2 Protein, Human (HEK293, His)	Q14108 (R27-T432)	≥ 95%, as determined by reducing SDS-PAGE.

SCARB2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82822	LIMPII Antibody (YA2567)	WB, IHC-P, ICC/IF	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure	Action Myoclonus-Renal Failure Syndrome EPM4 Amrf Myoclonus-Nephropathy Syndrome Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure Action Myoclonus - Renal Failure Syndrome Familial Myoclonus With Renal Failure Progressive Myoclonus Epilepsy With Renal Failure Progressive Myoclonic Epilepsy Type 4 Progressive Myoclonus Epilepsy Type 4 Epilepsy, Progressive Myoclonic, Type 4, With Or Without Renal Failure
Myoclonic Epilepsy Of Unverricht And Lundborg	Progressive Myoclonic Epilepsy Uld EPM1 Pme Epm1a Baltic Myoclonic Epilepsy Progressive Myoclonic Epilepsy Type 1 Unverricht-Lundborg Disease Familial Progressive Myoclonic Epilepsy Epilepsy, Progressive Myoclonic 1 Epilepsy, Progressive Myoclonic, 1a Epilepsy, Progressive Myoclonic, 1 Myoclonic Epilepsy, Progressive Epilepsy, Progressive Myoclonic 1a Progressive Myoclonus Epilepsy Type 1 Progressive Myoclonus Epilepsy Epilepsy Progressive Myoclonic Progressive Myoclonic Epilepsy 1 Progressive Myoclonic Epilepsy 1a Progressive Myoclonic Epilepsy Unverricht-Lundborg Type Epilepsy, Myoclonic, Progressive Epilepsy, Myoclonic, Progressive, Type 1a Unverricht-Lundborg Syndrome Myoclonic Epilepsies, Progressive
Myoclonus Epilepsy	Epilepsies, Myoclonic
Progressive Myoclonus Epilepsy	Pme Progressive Myoclonic Epilepsy Myoclonic Epilepsies, Progressive Unverricht-Lundborg Syndrome
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
Mouth Disease	Mouth Diseases Mouth Disorders
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Myoclonus
Progressive Myoclonus Epilepsy 4	Action Myoclonus-Renal Failure Syndrome Amrf Epm4 Myoclonus-Nephropathy Syndrome
Platelet Glycoprotein Iv Deficiency	Platelet-Type Bleeding Disorder 10 Bdplt10 Cd36 Deficiency Bleeding Disorder, Platelet-Type, 10 PG4D Bleeding Disorder Platelet-Type 10 Deficiency, Platelet Glycoprotein Iv
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Aortic Atherosclerosis	Atherosclerosis Of Aorta Aorta Atheroma Aorta Calcification Aorta Arteriosclerosis Aortic Degeneration Aortic Calcification Aortic Atheroma Aortic Arteriosclerotic Disease Aortic Arteriosclerosis Aorta Sclerosis Aorta Degeneration Atheromatous Aortic Calcified Aortic Stenosis Atheromatous Aorta Arteriosclerotic Aortitis Arteriosclerotic Aortic Stenosis Arteriosclerotic Aorta Disease Aortic Sclerosis
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Erythema Infectiosum	Fifth Disease Slapped Cheek Syndrome Parvovirus B19 Infection
Acute Hemorrhagic Encephalitis
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Late Congenital Syphilis	Juvenile Neurosyphilis Neurosyphilis, Juvenile
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12489	SCARB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18568	Scarb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25052	Scarb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SCARB2	VGNC	VGNC:45899
Rattus norvegicus	SCARB2	RGD	RGD:621882
Mus musculus	SCARB2	MGD	MGI:1196458
Felis catus	SCARB2	VGNC	VGNC:64902
Bos taurus	SCARB2	VGNC	VGNC:34325
Macaca mulatta	SCARB2	VGNC	VGNC:77026
Others	SCARB2	NCBI