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Referencia número: HY-117285

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Medermycin

(Synonyms: Lactoquinomycin A; LQM-A)

Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID₅₀ (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively.

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No. CAS: 60227-09-0
Fòrmula: C₂₄H₂₇NO₈
Peso molecular:457.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Medermycin Chemical Structure

No. CAS: 60227-09-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Antibiotic :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.043 μM Compound: 5	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 30209946]
MDA-MB-468	IC₅₀	0.05 μM Compound: 1, lactoquinomycin	Cytotoxicity against human MDA468 cells expressing AKT Cytotoxicity against human MDA468 cells expressing AKT	[PMID: 19309081]
PC-3	IC₅₀	0.015 μM Compound: 5	Cytotoxicity against human PC3 cells after 72 hrs by SRB assay Cytotoxicity against human PC3 cells after 72 hrs by SRB assay	[PMID: 30209946]

Chemical Information

No. CAS 60227-09-0
Peso molecular 457.47
Fòrmula C₂₄H₂₇NO₈
SMILES

O=C1C2=C(C(C3=C(O)C([C@H]4C[C@H]([C@@H]([C@H](O4)C)O)N(C)C)=CC=C31)=O)[C@@H](C)O[C@@](C5)([H])[C@]2([H])OC5=O
Synonyms

Lactoquinomycin A; LQM-A
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces albolongus strain CA-186053
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Beomkoo Chung, et al. Antibacterial Activity and Mode of Action of Lactoquinomycin A from Streptomyces bacillaris. Mar Drugs. 2020 Dec 24;19(1):7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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Chemical Information
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Medermycin

Ver todos los productos específicos de isoformas Antibiotic

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Medermycin Related Classifications

HY-117285 Related Classifications