country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-122163

Copy Link Print Information

MK-3901

MK-3901 is a selective P2X3 receptor antagonist with an IC₅₀ of 24 nM. MK-3901 inhibits UGT1A1 (with an IC₅₀ of 1 μM) and CYP2C9 (with an IC₅₀ of 5.7 μM). MK-3901 activates PXR. MK-3901 induces hyperbilirubinemia. MK-3901 can be used for the research of inflammatory pain.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1149750-69-5
Fòrmula: C₂₈H₂₄FN₅O₂
Peso molecular:481.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-3901 Chemical Structure

No. CAS: 1149750-69-5

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

P2X3 Receptor

24 nM (IC₅₀)

CYP2C9

5.7 μM (IC₅₀)

UGT1A1

1 μM (IC₅₀)

Ver todos los productos específicos de isoformas P2X Receptor :

Ver todos los productos específicos de isoformas Cytochrome P450 :

In Vitro

MK-3901 potently antagonizes the P2X3 receptor in a cell-based patch clamp electrophysiology assay with an IC₅₀ of 24 nM^[1].
MK-3901 inhibits UGT1A1 enzyme activity in a cell-free biochemical assay with an IC₅₀ of 1 μM^[1].
MK-3901 inhibits CYP2C9 enzyme activity in a human liver microsome-based cell-free biochemical assay with an IC₅₀ of 5.7 μM^[1].
MK-3901 (10 μM) activates the pregnane X receptor (PXR) by 47%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-3901 is demonstrated to induce hyperbilirubinemia in multiple species in preclinical studies^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1149750-69-5
Peso molecular 481.53
Fòrmula C₂₈H₂₄FN₅O₂
SMILES

C(N[C@H](C)C1=CC=C(F)C=N1)(=O)C2=CC(=CC(=C2)C3=CC=C(C)C=N3)C=4C[C@H](ON4)C5=CC=CC=N5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ginnetti AT, et al. Identification of second-generation P2X3 antagonists for treatment of pain. Bioorg Med Chem Lett. 2018;28(8):1392-1396. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

MK-3901

Ver todos los productos específicos de isoformas P2X Receptor

Ver todos los productos específicos de isoformas Cytochrome P450

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MK-3901 Related Classifications

HY-122163 Related Classifications