2. Gene
  3. Mir125a - microRNA 125a Gene

Mir125a - microRNA 125a Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-125a

Gene ID: 100314236 | Gene type: ncRNA

About Mir125a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in L-ascorbic acid metabolic process IDA
IDA: Inferred from direct assay
27085842 RGD
involved in cellular response to cortisone stimulus IEP
IEP: Inferred from expression pattern
23045399 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32319638 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
29700287 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
30156956 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
29700287 RGD
involved in negative regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
30972208 RGD
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
29700287 RGD
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
29319166 RGD
involved in negative regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
29700287 RGD
involved in negative regulation of vascular associated smooth muscle cell migration IDA
IDA: Inferred from direct assay
32319638 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
29700287 RGD
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
29319166 RGD
involved in positive regulation of vascular associated smooth muscle cell apoptotic process IDA
IDA: Inferred from direct assay
29700287 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
30156956 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
30156956 RGD
involved in regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
31490757 RGD
involved in regulation of progesterone biosynthetic process IDA
IDA: Inferred from direct assay
23045399 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00164 hsa-miR-125a-5p mimic 94.91% Unkown
HY-RI00164 hsa-miR-125a-5p inhibitor 97.48% Unkown
HY-R00163 hsa-miR-125a-3p mimic / Unkown
HY-R00163A hsa-miR-125a-3p agomir / Unkown
HY-R00164A hsa-miR-125a-5p agomir / Unkown
HY-RI00163 hsa-miR-125a-3p inhibitor / Unkown
HY-RI00163A hsa-miR-125a-3p antagomir / Unkown
HY-RI00164A hsa-miR-125a-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir125a NCBI NCBI:406910