1. Gene
  2. CST8 - cystatin 8 Gene

CST8 - cystatin 8 Gene

Homo sapiens

Also known as CRES; CTES5

Gene ID: 10047 | Gene type: protein coding

About CST8

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,491,117-23,507,124 (from NCBI)

This gene has 2 transcripts (splice variants), 149 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 2.7).

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CST8 Products(2)

mRNA Protein Name
NM_001281730.2 NP_001268659.1 cystatin-8 precursor
NM_005492.4 NP_005483.1 cystatin-8 precursor

CST8 Protein Structure

Cystatin

Cystatin: Cystatin domain (35 - 128)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

cystatin-8

cystatin 8 (cystatin-related epididymal specific)

Recombinant CST8 Proteins

Cat. No. Product Name Accession Purity
HY-P76851 Cystatin B/CST8 Protein, Human (HEK293, Fc) O60676 (M1-A142) ≥95%

Related Diseases

Diseases Alias
Encapsulated Thymoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus CST8 MGD MGI:107161
Canis familiaris CST8 VGNC VGNC:39680
Bos taurus CST8 VGNC VGNC:27778
Rattus norvegicus CST8 RGD RGD:2434
Macaca mulatta CST8 VGNC VGNC:84582
Felis catus CST8 VGNC VGNC:61238
Others CST8 NCBI