ARFRP1 - ADP ribosylation factor related protein 1 Gene

Also Known as ARP; Arp1; ARL18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10139

About ARFRP1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,698,647-63,707,976 (from NCBI)

Ubiquitous expression in spleen (RPKM 7.0), fat (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

ARFRP1 Products (8)

mRNA	Protein	Name
NM_001134758.4	NP_001128230.1	ADP-ribosylation factor-related protein 1 isoform b
NM_001267544.3	NP_001254473.1	ADP-ribosylation factor-related protein 1 isoform c
NM_001267545.3	NP_001254474.1	ADP-ribosylation factor-related protein 1 isoform d
NM_001267546.3	NP_001254475.1	ADP-ribosylation factor-related protein 1 isoform e
NM_001267547.3	NP_001254476.1	ADP-ribosylation factor-related protein 1 isoform a
NM_001267548.3	NP_001254477.1	ADP-ribosylation factor-related protein 1 isoform a
NM_001267549.3	NP_001254478.1	ADP-ribosylation factor-related protein 1 isoform b
NM_003224.6	NP_003215.1	ADP-ribosylation factor-related protein 1 isoform a

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	16129887	GOA
involved in protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	19224922	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	16129887	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19224922	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16129887	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARFRP1 Protein Structure

Arf

0
100
201 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-related protein 1	ARF-related protein 1

ARFRP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81894	ARFRP1 Antibody (YA1639)	WB, IP	Rat
HY-P81894A	ARFRP1 Antibody (YA1639)(PBS only)	WB, IP	Rat

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Hematocele Of Tunica Vaginalis Testis	Hematocele Male Hematocele
Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma	Mednik Syndrome Erythrokeratodermia Variabilis 3 MEDNIK Ekv3 Erythrokeratodermia Variabilis, Kamouraska Type Mental Retardation, Enteropathy, Deafness, Neuropathy, Ichthyosis, Keratodermia Intellectual Disability-Enteropathy-Deafness-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome Intellectual Disability-Enteropathy-Hearing Loss-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome Intellectual Disability, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma Erythrokeratodermia Variabilis Kamouraska Type Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, Keratoderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00906	ARFRP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARFRP1	VGNC	VGNC:98510
Rattus norvegicus	ARFRP1	RGD	RGD:621683
Bos taurus	ARFRP1	VGNC	VGNC:26069
Macaca mulatta	ARFRP1	VGNC	VGNC:70003
Mus musculus	ARFRP1	MGD	MGI:1923938
Canis familiaris	ARFRP1	VGNC	VGNC:38040