PRG4 - proteoglycan 4 Gene

Also Known as MSF; SZP; CACP; HAPO; JCAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10216

About PRG4

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,296,273-186,314,567 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in liver (RPKM 61.2), fat (RPKM 6.6) and 1 other tissue.

Summary

The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

PRG4 Products (5)

mRNA Protein Name
NM_001127708.3 NP_001121180.2 proteoglycan 4 isoform B preproprotein
NM_001127709.3 NP_001121181.2 proteoglycan 4 isoform C preproprotein
NM_001127710.3 NP_001121182.2 proteoglycan 4 isoform D preproprotein
NM_001303232.2 NP_001290161.1 proteoglycan 4 isoform E preproprotein
NM_005807.6 NP_005798.3 proteoglycan 4 isoform A preproprotein

PRG4 Protein Structure

Somatomedin_B

Somatomedin_B: Somatomedin B domain (27 - 68)

Somatomedin_B

Somatomedin_B: Somatomedin B domain (67 - 106)

Hemopexin

Hemopexin: Hemopexin (1195 - 1237)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1404 a.a.
Protein Preferred Names Protein Names

proteoglycan 4

  • articular superficial zone protein

Related Diseases

Diseases Alias
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

  • Jacobs Syndrome

  • Arthropathy-Camptodactyly Syndrome

  • Pericarditis-Arthropathy-Camptodactyly Syndrome

  • Xyy Syndrome

  • Pac Syndrome

  • Cacp Syndrome

  • CACP

  • Fibrosing Serositis, Familial

  • Camptodactyly-Arthropathy-Pericarditis Syndrome

  • Cap Syndrome

  • 47, Xyy Syndrome

  • 47,Xyy Syndrome

  • Double Y Syndrome

  • Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

  • Hypertrophic Synovitis, Congenital Familial

  • Congenital Familial Hypertrophic Synovitis

  • Xyy Karyotype

  • Y Disomy

  • Yy Syndrome

  • Familial Fibrosing Serositis

  • Disomy Y

  • Double Y

  • Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

  • Arthropathy Camptodactyly Syndrome

  • Camptodactyly Arthropathy Pericarditis Syndrome

  • Pericarditis Arthropathy Camptodactyly Syndrome

  • Jacob'S Syndrome

  • 47,Xyy

  • Cdags Syndrome
Pericarditis
Arthropathy

  • Ankylosis Of Ankle And Foot Joint

  • Ankylosis Of Forearm Joint

  • Ankylosis Of Hand Joint

  • Ankylosis Of Joint Of Ankle And/Or Foot

  • Ankylosis Of Joint Of Forearm

  • Ankylosis Of Joint Of Hand

  • Ankylosis Of Joint Of Lower Leg

  • Ankylosis Of Joint Of Multiple Sites

  • Ankylosis Of Joint Of Pelvic Region And Thigh

  • Ankylosis Of Joint Of Shoulder Region

  • Ankylosis Of Joint Of Upper Arm

  • Ankylosis Of Lower Leg Joint

  • Ankylosis Of Multiple Joints

  • Ankylosis Of Upper Arm Joint

  • Infectious Arthropathy

  • Joint Ankylosis Of The Ankle And Foot

  • Joint Ankylosis Of The Ankle And/Or Foot

  • Joint Ankylosis Of The Forearm

  • Joint Ankylosis Of The Hand

  • Joint Ankylosis Of The Lower Leg

  • Joint Ankylosis Of The Pelvic Region And Thigh

  • Joint Ankylosis Of The Shoulder Region

  • Joint Ankylosis Of The Upper Arm

  • Joint Diseases

  • Joint Disease

  • Arthropathy Associated With Infection
Coxa Vara
Synovitis
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Double Pterygium
Heel Spur

  • Calcaneal Spur
Pericardium Disease
Cartilage Disease

  • Cartilage Diseases

  • Cartilage

  • Cartilage Disorder

  • Chondropathy

  • Cartilage Disorders
Osteochondritis Dissecans

  • Osteochondritis

  • Ocd

  • Konig Disease
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11090 PRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19634 Prg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26129 Prg4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRG4 VGNC VGNC:33314
Canis familiaris PRG4 VGNC VGNC:53626
Macaca mulatta PRG4 VGNC VGNC:100048
Mus musculus PRG4 MGD MGI:1891344
Rattus norvegicus PRG4 RGD RGD:1308976
Others PRG4 NCBI