FSTL3 - follistatin like 3 Gene

Also Known as FLRG; FSRP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10272

About FSTL3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:676,392-683,385 (from NCBI)

This gene has 7 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 39 phenotypes. Biased expression in placenta (RPKM 92.4), testis (RPKM 32.9) and 13 other tissues.

Summary

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

FSTL3 Products (1)

mRNA	Protein	Name
NM_005860.3	NP_005851.1	follistatin-related protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables activin binding	IPI IPI: Inferred from physical interaction	12697670	GOA
enables fibronectin binding	IPI IPI: Inferred from physical interaction	16336961	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15574124	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	15451575	GOA
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	17878677	GOA
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	11948405	GOA
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	15574124	GOA
involved in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IDA IDA: Inferred from direct assay	17878677	GOA
involved in positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	16336961	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17868029	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11948405	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16150905	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16150905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSTL3 Protein Structure

FOLN

Kazal_2

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
follistatin-related protein 3	follistatin-like 3 (secreted glycoprotein)

FSTL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FSTL3	O95633	ADAM12	Homo sapiens	O43184-2	Anti Tag CoIP	15574124
Intra	FSTL3	O95633	ADAM12	Homo sapiens	O43184-2	Y2H	15574124

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FSTL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77941	FSTL3 Protein, Human (HEK293, His)	O95633 (M27-V263)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Chronic Leukemia	Adult Chronic Leukemia Cll Cml

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05129	FSTL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17504	Fstl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23961	Fstl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FSTL3	VGNC	VGNC:40999
Bos taurus	FSTL3	VGNC	VGNC:29136
Mus musculus	FSTL3	MGD	MGI:1890391
Rattus norvegicus	FSTL3	RGD	RGD:621811
Felis catus	FSTL3	VGNC	VGNC:62381
Others	FSTL3	NCBI