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PRG3 - proteoglycan 3, pro eosinophil major basic protein 2 Gene

Also Known as MBP2; MBPH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10394

About PRG3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,376,769-57,381,150 (from NCBI)

This gene has 1 transcript (splice variant), 110 orthologues and 1 paralogue. Restricted expression toward bone marrow (RPKM 15.2).

Summary

An extracellular matrix structural constituent conferring compression resistance. Involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

PRG3 Products (1)

mRNA	Protein	Name
NM_006093.4	NP_006084.2	proteoglycan 3 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in basophil activation	IDA IDA: Inferred from direct assay	10318872	GOA
involved in histamine biosynthetic process	IDA IDA: Inferred from direct assay	10318872	GOA
involved in leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	10318872	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	10318872	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	10318872	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	10318872	GOA
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	10318872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRG3 Protein Structure

Lectin_C

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
proteoglycan 3	eosinophil major basic protein homolog

Recombinant PRG3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71233	PRG3 Protein, Human (HEK293, His)	AAI13412.1 (L18-F225)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Oropouche Fever	Oropouche Virus Disease Oropouche Mosquito-Borne Viral Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00493	AIFM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11089	PRG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17756	Aifm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19940	Prg3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24223	Aifm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26442	Prg3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRG3	RGD	RGD:1309904
Felis catus	PRG3	VGNC	VGNC:104346
Mus musculus	PRG3	MGD	MGI:1858200
Macaca mulatta	PRG3	VGNC	VGNC:76397
Canis familiaris	PRG3	VGNC	VGNC:52036
Others	PRG3	NCBI