BASP1 - brain abundant membrane attached signal protein 1 Gene

Also Known as CAP23; NAP22; CAP-23; NAP-22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10409

About BASP1

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:17,216,823-17,276,834 (from NCBI)

This gene has 3 transcripts (splice variants) and 110 orthologues. Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues.

Summary

This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

BASP1 Products (2)

mRNA	Protein	Name
NM_001271606.2	NP_001258535.1	brain acid soluble protein 1
NM_006317.5	NP_006308.3	brain acid soluble protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	32750402	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	14701728	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	14701728	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19050011	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14701728	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	32750402	GOA
involved in supramolecular fiber organization	IDA IDA: Inferred from direct assay	32750402	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in PML body	IDA IDA: Inferred from direct assay	19050011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14701728	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	19050011	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14701728	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BASP1 Protein Structure

BASP1

0
100
200
227 a.a.

Protein Preferred Names	Protein Names
brain acid soluble protein 1	22 kDa neuronal tissue-enriched acidic protein

Related Diseases

Diseases	Alias
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS01370	BASP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20368	Basp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26878	Basp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BASP1	VGNC	VGNC:70228
Bos taurus	BASP1	VGNC	VGNC:106649
Rattus norvegicus	BASP1	RGD	RGD:621491
Mus musculus	BASP1	MGD	MGI:1917600
Canis familiaris	BASP1	VGNC	VGNC:38384
Others	BASP1	NCBI