Isl2 - insulin related protein 2 (islet 2) Gene

Also Known as 3110001N10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104360

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb ectoderm; retina; and spinal ganglion. Orthologous to human ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Isl2 Products (1)

mRNA Protein Name
NM_027397.3 NP_081673.2 insulin gene enhancer protein ISL-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24643061 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
14766174 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
14766174 MGI
acts upstream of or within neuron fate commitment IGI
IGI: Inferred from genetic interaction
14766174 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
14766174 MGI
acts upstream of or within retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
15537545 MGI
acts upstream of or within spinal cord motor neuron cell fate specification IGI
IGI: Inferred from genetic interaction
19666821 MGI
acts upstream of or within visceral motor neuron differentiation IGI
IGI: Inferred from genetic interaction
14766174 MGI
acts upstream of or within visceral motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
14766174 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25433207 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin gene enhancer protein ISL-2

  • islet 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06932 ISL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isl2 NCBI NCBI:64843