OLFM1 - olfactomedin 1 Gene

Also Known as AMY; NOE1; OlfA; NOELIN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10439

About OLFM1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,075,505-135,121,184 (from NCBI)

This gene has 12 transcripts (splice variants), 270 orthologues and 9 paralogues. Biased expression in brain (RPKM 118.4), adrenal (RPKM 7.6) and 1 other tissue.

Summary

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OLFM1 Products (4)

mRNA Protein Name
NM_001282611.2 NP_001269540.1 noelin isoform 4 precursor
NM_001282612.1 NP_001269541.1 noelin isoform 5
NM_006334.4 NP_006325.1 noelin isoform 2 precursor
NM_014279.5 NP_055094.1 noelin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17043677 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16751333 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM1 Protein Structure

Noelin-1

Noelin-1: Neurogenesis glycoprotein (54 - 152)

OLF

OLF: Olfactomedin-like domain (230 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

noelin

  • neuroblastoma protein

OLFM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OLFM1 Q99784 DISC1 Homo sapiens Q9NRI5-1
Y2H
17043677
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcosinemia

  • Sarcosine Dehydrogenase Complex Deficiency

  • Sard Deficiency

  • Sardh Deficiency

  • SARCOS

  • Hypersarcosinemia

  • Sardhd

  • Demethylation Defect Of N-Methylglycine
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09770 OLFM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21677 Olfm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28195 Olfm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OLFM1 VGNC VGNC:75416
Felis catus OLFM1 VGNC VGNC:63958
Rattus norvegicus OLFM1 RGD RGD:620320
Canis familiaris OLFM1 VGNC VGNC:55713
Bos taurus OLFM1 VGNC VGNC:32417
Mus musculus OLFM1 MGD MGI:1860437
Others OLFM1 NCBI