SCGN - secretagogin, EF-hand calcium binding protein Gene

Also Known as SEGN; CALBL; SECRET; setagin; DJ501N12.8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10590

About SCGN

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:25,652,215-25,701,783 (from NCBI)

This gene has 2 transcripts (splice variants), 267 orthologues and 2 paralogues. Biased expression in stomach (RPKM 11.2), colon (RPKM 8.7) and 8 other tissues.

Summary

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

SCGN Products (1)

mRNA Protein Name
NM_006998.4 NP_008929.2 secretagogin

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCGN Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (111 - 177)

EF-hand_5

EF-hand_5: EF hand (249 - 267)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

secretagogin

SCGN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCGN O76038 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
SCGN O76038 SNAP23 Homo sapiens O00161
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCGN Proteins

Cat. No. Product Name Accession Purity
HY-P71042 SCGN Protein, Human (HEK293, His) O76038 (M1-P276) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76050 SCGN Protein, Human (His) O76038 (D2-P276) ≥ 95%, as determined by reducing SDS-PAGE.

SCGN Antibodies

Cat. No. Product Name Application Reactivity
HY-P81422 SCGN Antibody (YA1167) IHC-P Human
HY-P81422A SCGN Antibody (YA1167)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Insulinoma

  • Islet Cell Adenoma

  • Insulin-Producing Tumor Of Islet Cells

  • Adenoma Islet Cell

  • Islet Cell Tumor

  • Experimental Organism Islet Cell Adenoma Neoplasm
Fanconi Renotubular Syndrome 2

  • FRTS2

  • Fanconi Renotubular Syndrome, Type 2
Neuroendocrine Tumor

  • Neuroendocrine Neoplasm

  • Neuroendocrine Tumors

  • Carcinoma, Neuroendocrine
Central Neurocytoma

  • Neurocytoma

  • Neurolipocytoma

  • Neurocytoma Central
Labyrinthitis

  • Labyrinthine Disorder

  • Inner Ear Inflammation

  • Otitis Interna

  • Labyrinth Hyperaemia
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12509 SCGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19641 Scgn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26134 Scgn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCGN VGNC VGNC:77030
Bos taurus SCGN VGNC VGNC:34337
Rattus norvegicus SCGN RGD RGD:1303281
Canis familiaris SCGN VGNC VGNC:45909
Mus musculus SCGN MGD MGI:2384873
Felis catus SCGN VGNC VGNC:64913
Others SCGN NCBI