Asmt - acetylserotonin O-methyltransferase Gene

Also Known as Hiomt

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107626

Summary

This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from Other strains. [provided by RefSeq, May 2015]

Asmt Products (2)

mRNA Protein Name
NM_001199212.1 NP_001186141.1 acetylserotonin O-methyltransferase isoform 1
NM_001308488.2 NP_001295417.1 acetylserotonin O-methyltransferase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetylserotonin O-methyltransferase activity IDA
IDA: Inferred from direct assay
20308563 MGI
enables acetylserotonin O-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
3941912 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of male gonad development IMP
IMP: Inferred from mutant phenotype
20308563 MGI
acts upstream of or within melatonin biosynthetic process IDA
IDA: Inferred from direct assay
20308563 MGI
acts upstream of or within melatonin biosynthetic process IMP
IMP: Inferred from mutant phenotype
3941912 MGI
acts upstream of or within negative regulation of male gonad development IMP
IMP: Inferred from mutant phenotype
20308563 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetylserotonin O-methyltransferase

  • hydroxyindole O-methyltransfease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01096 ASMT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asmt NCBI NCBI:438