ASMT - acetylserotonin O-methyltransferase Gene

Homo sapiens

Also known as ASMTY; HIOMT; HIOMTY

Gene ID: 438 | Gene type: protein coding

About ASMT

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,595,455-1,643,081 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 1.4), bone marrow (RPKM 1.3) and 25 other tissues.

Summary

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded Enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

ASMT Products(3)

mRNA	Protein	Name
NM_001171038.2	NP_001164509.1	acetylserotonin O-methyltransferase isoform 1
NM_001171039.1	NP_001164510.1	acetylserotonin O-methyltransferase isoform 2
NM_004043.3	NP_004034.2	acetylserotonin O-methyltransferase isoform 1

ASMT Protein Structure

Methyltransf_2

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

acetylserotonin O-methyltransferase

acetylserotonin N-methyltransferase

Related Diseases

Diseases

Alias

Pineoblastoma

Pineal Pnet	Pinealoma
Pineal Gland Neoplasm	Pineocytoma
Tumor Of The Pineal Region

Pineocytoma

Pinealoma	Pinealocytoma
Pineal Gland Neoplasm	Tumor Of The Pineal Region

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation	Pineal Parenchymal Tumors Of Intermediate Differentiation
Pptid

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01096	ASMT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ASMT	MGD	MGI:96090
Rattus norvegicus	ASMT	RGD	RGD:708472