Thoc5 - THO complex 5 Gene

Also Known as Fmip; Sgk2; PK1.3; 1700060C24Rik; A430085L24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107829

Summary

Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex 5). [provided by Alliance of Genome Resources, Apr 2022]

Thoc5 Products (1)

mRNA Protein Name
NM_172438.3 NP_766026.1 THO complex subunit 5 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IMP
IMP: Inferred from mutant phenotype
24315442 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10597251 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
24315442 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
24315442 MGI
acts upstream of or within negative regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
10597251 MGI
involved in primitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
20051105 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24315442 MGI
acts upstream of or within regulation of mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
24315442 MGI
acts upstream of or within regulation of stem cell division IMP
IMP: Inferred from mutant phenotype
24315442 MGI
acts upstream of or within stem cell division IMP
IMP: Inferred from mutant phenotype
24315442 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24315442 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
15221008 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

THO complex subunit 5 homolog

  • Fms interacting protein

  • fms-interacting protein

  • serum/glucocorticoid regulated kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14494 THOC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thoc5 NCBI NCBI:8563