Rcc2 - regulator of chromosome condensation 2 Gene

Also Known as Td60; mKIAA1470; 2610510H01Rik; 2610529N02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108911

Summary

Enables small GTPase binding activity. Involved in several processes, including negative regulation of cell-substrate adhesion; regulation of GTPase activity; and regulation of ruffle assembly. Located in early endosome membrane; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Apr 2022]

Rcc2 Products (1)

mRNA Protein Name
NM_173867.5 NP_776292.1 protein RCC2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables small GTPase binding IPI
IPI: Inferred from physical interaction
25074804 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of GTPase activity IGI
IGI: Inferred from genetic interaction
25074804 MGI
involved in establishment of protein localization IGI
IGI: Inferred from genetic interaction
25074804 MGI
involved in negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
19738201 MGI
involved in negative regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
19738201 MGI
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19738201 MGI
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19738201 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
25074804 MGI
involved in regulation of ruffle assembly IGI
IGI: Inferred from genetic interaction
25074804 MGI
involved in regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
25074804 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
25074804 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25074804 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
25074804 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein RCC2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139782 SKLB325 99.21% Unkown
HY-RS11784 RCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rcc2 NCBI NCBI:55920