RCC2 - regulator of chromosome condensation 2 Gene

Also Known as TD-60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55920

About RCC2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,406,760-17,439,677 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 29.5), skin (RPKM 28.3) and 25 other tissues.

Summary

The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early Mitosis. This protein has been shown to be a biomarker for colorectal Cancer. [provided by RefSeq, Oct 2016]

RCC2 Products (2)

mRNA Protein Name
NM_001136204.3 NP_001129676.1 protein RCC2
NM_018715.4 NP_061185.1 protein RCC2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
12919680 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22282019 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
25074804 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25074804 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
12919680 GOA
Biological Process GO Annotation Evidence References Source
involved in chromosome passenger complex localization to kinetochore IMP
IMP: Inferred from mutant phenotype
12919680 GOA
involved in focal adhesion assembly IDA
IDA: Inferred from direct assay
19738201 GOA
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
19738201 GOA
involved in negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
25074804 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12919680 GOA
involved in positive regulation of attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
12919680 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric core domain IDA
IDA: Inferred from direct assay
12919680 GOA
colocalizes with membrane IDA
IDA: Inferred from direct assay
25074804 GOA
located in midbody IDA
IDA: Inferred from direct assay
12919680 GOA
located in mitotic spindle midzone IDA
IDA: Inferred from direct assay
12919680 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCC2 Protein Structure

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (168 - 217)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (221 - 268)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (272 - 345)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (350 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

protein RCC2

  • RCC1-like protein TD-60

Related Diseases

Diseases Alias
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139782 SKLB325 99.21% Unkown
HY-RS11784 RCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RCC2 VGNC VGNC:33827
Macaca mulatta RCC2 VGNC VGNC:100054
Canis familiaris RCC2 VGNC VGNC:45441
Felis catus RCC2 VGNC VGNC:64546
Mus musculus RCC2 MGD MGI:1919784
Rattus norvegicus RCC2 RGD RGD:1309986
Others RCC2 NCBI