MMP24 - matrix metallopeptidase 24 Gene

Also Known as MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10893

About MMP24

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,226,690-35,276,998 (from NCBI)

This gene has 1 transcript (splice variant), 198 orthologues and 23 paralogues. Broad expression in kidney (RPKM 9.9), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins Cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

MMP24 Products (1)

mRNA Protein Name
NM_006690.4 NP_006681.1 matrix metalloproteinase-24 preproprotein

MMP24 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (80 - 134)

Peptidase_M10

Peptidase_M10: Matrixin (162 - 327)

Hemopexin

Hemopexin: Hemopexin (388 - 426)

Hemopexin

Hemopexin: Hemopexin (429 - 467)

Hemopexin

Hemopexin: Hemopexin (476 - 522)

Hemopexin

Hemopexin: Hemopexin (526 - 569)

DUF3377

DUF3377: Domain of unknown function (DUF3377) (573 - 645)

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  • 645 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-24

  • matrix metallopeptidase 24 (membrane-inserted)

Related Diseases

Diseases Alias
Acromesomelic Dysplasia 2c

  • Acromesomelic Dysplasia, Hunter-Thompson Type

  • Acromesomelic Dysplasia 2c, Hunter-Thompson Type

  • AMD2C

  • Acromesomelic Dwarfism

  • Amdh Acromesomelic Dwarfism

  • Acromesomelic Dysplasia-2c

  • Acromesomelic Dysplasia Hunter Thompson Type

  • Acromesomelic Chondrodysplasia, Hunter-Thompson Type

  • Amdh

  • Dysplasia, Acromesomelic, Type 2c, Hunter-Thompson

  • Acromesomelic Dysplasia Hunter-Thompson Type
Charcot-Marie-Tooth Disease, Axonal, Type 2dd

  • CMT2DD

  • Charcot-Marie-Tooth Neuropathy, Type 2dd

  • Charcot-Marie-Tooth Disease Type 2dd

  • Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

  • Atp1a1-Related Cmt2

  • Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd

  • Charcot-Marie-Tooth Disease 2dd
Winchester Syndrome

  • WNCHRS

  • Winchester Disease

  • Winchester-Grossman Syndrome
Asymptomatic Dengue
Suppurative Periapical Periodontitis

  • Periapical Abscess

  • Apical Abscess

  • Suppurative Apical Periodontitis

  • Dentoalveolar Abscess

  • Dental Abscess With Sinus

  • Dentoalveolar Abscess With Sinus

  • Dental Sinus

  • Periapical Abscess Fistula

  • Apical Tooth Abscess

  • Apex Abscess

  • Dental Abscess Nos

  • Infection Of Tooth Nos

  • Abscess Of Tooth

  • Dental Infection Nos
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

  • Cadasil

  • Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

  • Casil

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

  • Familial Vascular Leukoencephalopathy

  • CADASIL1

  • Cadasil 1

  • Hereditary Multi-Infarct Dementia

  • Cadasil Syndrome

  • Dementia, Hereditary Multiinfarct Type

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1

  • Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1

  • Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy

  • Dementia, Hereditary Multi-Infarct Type

  • Hereditary Dementia, Multi-Infarct Type

  • Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

  • Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1

  • Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant

  • Dementia Hereditary Multiinfarct Type

  • Dementia Hereditary Multi-Infarct Type

  • Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184183 MT5-MMP-IN-1 Inhibitor / Unkown
HY-RS08543 MMP24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MMP24 RGD RGD:620202
Canis familiaris MMP24 VGNC VGNC:43283
Mus musculus MMP24 MGD MGI:1341867
Bos taurus MMP24 VGNC VGNC:31526
Felis catus MMP24 VGNC VGNC:68289
Macaca mulatta MMP24 VGNC VGNC:74899
Others MMP24 NCBI