GLIPR1 - GLI pathogenesis related 1 Gene

Also Known as GLIPR; RTVP1; CRISP7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11010

About GLIPR1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,480,755-75,503,863 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues.

Summary

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate Cancer. The protein has proapoptotic activities in prostate and bladder Cancer cells. This gene is a member of a cluster on chromosome 12 containing two Other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GLIPR1 Products (1)

mRNA Protein Name
NM_006851.3 NP_006842.2 glioma pathogenesis-related protein 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLIPR1 Protein Structure

CAP

CAP: Cysteine-rich secretory protein family (39 - 175)

  • 0
  • 100
  • 200
  • 266 a.a.
Protein Preferred Names Protein Names

glioma pathogenesis-related protein 1

  • GLI pathogenesis-related 1 (glioma)

GLIPR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLIPR1 P48060 ALOXE3 Homo sapiens Q9BYJ1
Anti Tag CoIP
33961781
Intra
GLIPR1 P48060 ALOXE3 Homo sapiens Q9BYJ1
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GLIPR1 Proteins

Cat. No. Product Name Accession Purity
HY-P70359 GLIPR1 Protein, Human (HEK293, His) P48060-1 (A22-R232) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Glioma
D-Glyceric Aciduria

  • D-Glyceric Acidemia

  • D-Glycericacidemia

  • Glycerate Kinase Deficiency

  • D-Glycerate Kinase Deficiency

  • Non Ketotic Hyperglycinemia Syndrome

  • Deficiency Of Glycerate Kinase

  • Hyperglycinemia, Non-Ketotic

  • D-GA
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

  • Wilson-Turner Syndrome

  • WTS

  • Mrxs6

  • X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

  • Mrxswt

  • Wilson-Turner X-Linked Mental Retardation Syndrome

  • Mental Retardation, X-Linked, Syndromic 6

  • Mental Retardation, X-Linked, With Gynecomastia And Obesity

  • Intellectual Disability, X-Linked, Syndromic 6

  • Intellectual Disability, X-Linked, With Gynecomastia And Obesity

  • Wilson Turner Intellectual Disability Syndrome

  • X-Linked Intellectual Disability - Gynecomastia - Obesity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05478 GLIPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18564 Glipr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25046 Glipr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GLIPR1 VGNC VGNC:81411
Rattus norvegicus GLIPR1 RGD RGD:1305978
Mus musculus GLIPR1 MGD MGI:1920940
Felis catus GLIPR1 VGNC VGNC:84024
Bos taurus GLIPR1 VGNC VGNC:29402
Canis familiaris GLIPR1 VGNC VGNC:41260
Others GLIPR1 NCBI