OGFR - opioid growth factor receptor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11054

About OGFR

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,804,835-62,814,000 (from NCBI)

This gene has 3 transcripts (splice variants), 357 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.4), lung (RPKM 12.6) and 25 other tissues.

Summary

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

OGFR Products (1)

mRNA Protein Name
NM_007346.4 NP_031372.2 opioid growth factor receptor

OGFR Protein Structure

OGFr_N

OGFr_N: Opioid growth factor receptor (OGFr) conserved region (84 - 293)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (517 - 536)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (537 - 556)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (557 - 576)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (577 - 596)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (597 - 616)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (617 - 636)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (637 - 656)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
Protein Preferred Names Protein Names

opioid growth factor receptor

  • protein 7-60

OGFR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OGFR Q9NZT2 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
OGFR Q9NZT2 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Keratopathy
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09761 OGFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OGFR RGD RGD:69324
Bos taurus OGFR VGNC VGNC:32411
Macaca mulatta OGFR VGNC VGNC:75406
Mus musculus OGFR MGD MGI:1919325
Others OGFR NCBI