Aanat - arylalkylamine N-acetyltransferase Gene

Also Known as Nat4; Snat; Nat-2; AA-NAT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11298

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Aanat Products (1)

mRNA Protein Name
NM_009591.3 NP_033721.1 serotonin N-acetyltransferase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables arylamine N-acetyltransferase activity IDA
IDA: Inferred from direct assay
7545952 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serotonin N-acetyltransferase

  • aralkylamine N-acetyltransferase

  • serotonin acetylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157521 AANAT-IN-1 Inhibitor 99.87% Unkown
HY-179397 AANAT-IN-2 Inhibitor / Unkown
HY-RS00025 AANAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aanat NCBI NCBI:15