RBPJL - recombination signal binding protein for immunoglobulin kappa J region like Gene

Also Known as RBPL; SUHL; RBPSUHL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11317

About RBPJL

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,306,840-45,317,824 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Restricted expression toward pancreas (RPKM 78.6).

Summary

This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RBPJL Products (3)

mRNA Protein Name
NM_001281448.2 NP_001268377.1 recombining binding protein suppressor of hairless-like protein isoform 2
NM_001281449.2 NP_001268378.1 recombining binding protein suppressor of hairless-like protein isoform 3
NM_014276.4 NP_055091.2 recombining binding protein suppressor of hairless-like protein isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBPJL Protein Structure

LAG1-DNAbind

LAG1-DNAbind: LAG1, DNA binding (68 - 206)

BTD

BTD: Beta-trefoil DNA-binding domain (207 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
Protein Preferred Names Protein Names

recombining binding protein suppressor of hairless-like protein

  • transcription factor RBP-L

RBPJL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBPJL Q9UBG7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RBPJL Q9UBG7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Spontaneous Ocular Nystagmus

  • Visual Deprivation Nystagmus

  • Ocular Nystagmus

  • Searching Eye Movements

  • Nystagmus, Pathologic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11773 RBPJL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RBPJL VGNC VGNC:57020
Canis familiaris RBPJL VGNC VGNC:54727
Macaca mulatta RBPJL VGNC VGNC:84535
Felis catus RBPJL VGNC VGNC:81169
Rattus norvegicus RBPJL RGD RGD:1304786
Mus musculus RBPJL MGD MGI:1196616
Others RBPJL NCBI