Acadl - acyl-Coenzyme A dehydrogenase, long-chain Gene

Also Known as LCAD

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11363

Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

Acadl Products (1)

mRNA	Protein	Name
NM_007381.4	NP_031407.2	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables long-chain fatty acyl-CoA dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	9861014	MGI
enables palmitoyl-CoA oxidase activity	IMP IMP: Inferred from mutant phenotype	9861014	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in carnitine catabolic process	IMP IMP: Inferred from mutant phenotype	9861014	MGI
involved in carnitine metabolic process, CoA-linked	IMP IMP: Inferred from mutant phenotype	9861014	MGI
involved in cellular lipid catabolic process	IMP IMP: Inferred from mutant phenotype	9861014	MGI
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IMP IMP: Inferred from mutant phenotype	15639194	MGI
acts upstream of or within fatty acid catabolic process	IMP IMP: Inferred from mutant phenotype	21151927	MGI
involved in negative regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15639194	MGI
involved in negative regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	15639194	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	9802886	MGI
involved in regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	15639194	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	21151927	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	15639194	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	26767982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
long-chain specific acyl-CoA dehydrogenase, mitochondrial	acetyl-Coenzyme A dehydrogenase, long-chain

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19401	Acadl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00127	ACADL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25893	Acadl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acadl	NCBI	NCBI:33