ACADL - acyl-CoA dehydrogenase long chain Gene

Also Known as LCAD; ACAD4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 33

About ACADL

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,187,923-210,225,447 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 10.1), fat (RPKM 9.6) and 14 other tissues.

Summary

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four Enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]

ACADL Products (1)

mRNA Protein Name
NM_001608.4 NP_001599.1 long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACADL Protein Structure

Acyl-CoA_dh_N

Acyl-CoA_dh_N: Acyl-CoA dehydrogenase, N-terminal domain (54 - 165)

Acyl-CoA_dh_M

Acyl-CoA_dh_M: Acyl-CoA dehydrogenase, middle domain (169 - 219)

Acyl-CoA_dh_1

Acyl-CoA_dh_1: Acyl-CoA dehydrogenase, C-terminal domain (278 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 430 a.a.
Protein Preferred Names Protein Names

long-chain specific acyl-CoA dehydrogenase, mitochondrial

  • acyl-Coenzyme A dehydrogenase, long chain

ACADL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACADL P28330 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
ACADL P28330 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
ACADL P28330 SYT2 Homo sapiens Q8N9I0
Anti Tag CoIP
33961781
Intra
ACADL P28330 SYT2 Homo sapiens Q8N9I0
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of

  • Vlcad Deficiency

  • Very Long Chain Acyl-Coa Dehydrogenase Deficiency

  • Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency

  • Lcad Deficiency

  • Very Long-Chain Acyl-Coa Dehydrogenase Deficiency

  • Long Chain Acyl-Coa Dehydrogenase Deficiency

  • ACADVLD

  • Acadl Deficiency

  • Vlcadd

  • Long-Chain Acyl-Coa Dehydrogenase Deficiency

  • Acadvl

  • Acyl-Coa Dehydrogenase Very Long Chain Deficiency

  • Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency

  • Vlcad-C

  • Vlcad-H

  • Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of

  • Acyl-Coa Dehydrogenase Very Long-Chain Deficiency

  • Acyl-Coa Dehydrogenase Long-Chain Deficiency

  • Deficiency, Very Long Chain Acyl-Coa Dehydrogenase

  • Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency
Hypoglycemia

  • Hypoglycaemia

  • Low Blood Sugar

  • Hypoglycaemia Nos

  • Spontaneous Hypoglycaemia

  • Nondiabetic Hypoglycaemia

  • Hypoglycaemic Disorder Nos

  • Hypoglycaemic Syndrome
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of

  • Mcad Deficiency

  • Carnitine Deficiency Secondary To Medium-Chain Acyl-Coa Dehydrogenase Deficiency

  • Acadm Deficiency

  • Acyl-Coa Dehydrogenase, Medium Chain, Deficiency Of

  • Medium Chain Acyl-Coa Dehydrogenase Deficiency

  • ACADMD

  • Mcadh Deficiency

  • Mcadd

  • Medium Chain Acyl-Coenzyme A Dehydrogenase Deficiency

  • Acyl-Coa Dehydrogenase Medium-Chain Deficiency

  • Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency

  • Medium Chain Acyl Dehydrogenase Deficiency
Ureter Transitional Cell Carcinoma

  • Transitional Cell Carcinoma Of Ureter

  • Ureteral Urothelial Cell Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19401 Acadl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00127 ACADL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25893 Acadl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACADL MGD MGI:87866
Rattus norvegicus ACADL RGD RGD:2011
Bos taurus ACADL VGNC VGNC:25523
Felis catus ACADL VGNC VGNC:68769
Macaca mulatta ACADL VGNC VGNC:69594
Canis familiaris ACADL VGNC VGNC:37493
Others ACADL NCBI