SDSL - serine dehydratase like Gene

Also Known as TDH; cSDH; SDH 2; SDS-RS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113675

About SDSL

This gene has 6 transcripts (splice variants), 199 orthologues and 5 paralogues. Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in isoleucine biosynthetic process and threonine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SDSL Products (2)

mRNA Protein Name
NM_001304993.2 NP_001291922.1 serine dehydratase-like
NM_138432.4 NP_612441.1 serine dehydratase-like

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables L-serine ammonia-lyase activity IDA
IDA: Inferred from direct assay
16580895 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables threonine deaminase activity IDA
IDA: Inferred from direct assay
16580895 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDSL Protein Structure

PALP

PALP: Pyridoxal-phosphate dependent enzyme (15 - 310)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

serine dehydratase-like

  • L-serine deaminase

SDSL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Validated Y2H
32296183
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Y2H Array
25416956
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Y2H Prey Pooling
32296183
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Y2H Array
32296183
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Y2H Array
31515488
Intra
SDSL Q96GA7 SDSL Homo sapiens Q96GA7
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcocystosis

  • Sarcosporidiosis

  • Sarcosporidiasis
Subdural Empyema

  • Empyema, Subdural

  • Subdural Abscess
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12600 SDSL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SDSL VGNC VGNC:34400
Canis familiaris SDSL VGNC VGNC:45959
Felis catus SDSL VGNC VGNC:64958
Mus musculus SDSL MGD MGI:2182607
Macaca mulatta SDSL VGNC VGNC:77347
Rattus norvegicus SDSL RGD RGD:1309192
Others SDSL NCBI