2. Gene
  3. Sncb - synuclein, beta Gene

Sncb - synuclein, beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 113893 | Gene type: protein coding

About Sncb

Summary

Enables alpha-tubulin binding activity and beta-tubulin binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; regulation of neuron death; and synaptic vesicle endocytosis. Predicted to act upstream of or within dopamine metabolic process and negative regulation of neuron apoptotic process. Located in growth cone; neuronal cell body; and terminal bouton. Is active in presynaptic cytosol. Used to study uveitis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Apr 2022]

Sncb Products(1)

mRNA Protein Name
NM_080777.2 NP_542955.2 beta-synuclein
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
18800064 RGD
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
18800064 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon terminus IDA
IDA: Inferred from direct assay
12127102 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12821390 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11716559 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
7877458 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
10777786 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-synuclein

PNP 14

phosphoneuroprotein 14

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13486 SNCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sncb NCBI NCBI:6620