Gpnmb - glycoprotein nmb Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113955

Summary

Predicted to enable heparin binding activity; signaling receptor binding activity; and syndecan binding activity. Involved in bone mineralization and osteoblast differentiation. Predicted to be located in cytoplasmic vesicle. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]

Gpnmb Products (1)

mRNA Protein Name
NM_133298.1 NP_579832.1 transmembrane glycoprotein NMB precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in bone mineralization IEP
IEP: Inferred from expression pattern
11746512 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
11746512 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane glycoprotein NMB

  • glycoprotein (transmembrane) nmb

  • osteoactivin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-141604 Glembatumumab vedotin Inhibitor ≥99.0% Phase 2
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99205 Glembatumumab 99.69% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05648 GPNMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16622 Gpnmb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23057 Gpnmb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpnmb NCBI NCBI:10457