Nkx2-5 - NK2 homeobox 5 Gene

Also Known as Csx; Nkx2.5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114109

Summary

Enables several functions, including DNA-binding transcription factor activity; histone deacetylase binding activity; and identical protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of transcription by RNA polymerase II; and response to estradiol. Located in nucleus. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-5 Products (2)

mRNA Protein Name
NM_053651.2 NP_446103.2 homeobox protein Nkx-2.5
NM_053651.2 NP_446103.2 homeobox protein Nkx-2.5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12775767 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
19638401 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11042197 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17544441 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11042197 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell differentiation IEP
IEP: Inferred from expression pattern
20486789 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
19395679 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23744058 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19395679 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18832095 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.5

  • homeobox protein NK-2 homolog E

  • rNKx-2.5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160839 SPB-PEG4-AAD / Unkown
HY-103484 GATA4-NKX2-5-IN-1 Inhibitor 99.24% Unkown
HY-108440 Shz-1 99.88% Unkown
HY-RS09330 NKX2-5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-5 NCBI NCBI:1482