Akap1 - A-kinase anchoring protein 1 Gene

Also Known as Akap84

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114124

Summary

Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of protein dephosphorylation; and negative regulation of protein import into nucleus. Located in several cellular components, including lipid droplet; mitochondrial crista; and neuromuscular junction. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Akap1 Products (1)

mRNA Protein Name
NM_053665.1 NP_446117.1 A-kinase anchor protein 1, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
12096916 RGD
enables microtubule binding IDA
IDA: Inferred from direct assay
12096916 RGD
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
16756943 RGD
enables protein kinase A regulatory subunit binding IDA
IDA: Inferred from direct assay
16756943 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
9182549 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16996504 RGD
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
16756943 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9722570 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
9722570 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
19358331 RGD
involved in negative regulation of dephosphorylation IMP
IMP: Inferred from mutant phenotype
19358331 RGD
involved in negative regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
19358331 RGD
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
16756943 RGD
located in mitochondrial crista IDA
IDA: Inferred from direct assay
16996504 RGD
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
11716788 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
11716788 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
11716788 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: Inferred from direct assay
11716788 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 1, mitochondrial

  • A kinase (PRKA) anchor protein 1

  • A-kinase anchor protein 121 kDa

  • AKAP 121

  • D-AKAP-1

  • PRKA1

  • S-AKAP84

  • a kinase anchor protein 1, mitochondrial

  • dual specificity A-kinase-anchoring protein 1

  • protein kinase A-anchoring protein 1

  • spermatid A-kinase ancho

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS29476 Akap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00512 AKAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap1 NCBI NCBI:8165