Akap1 - A-kinase anchoring protein 1 Gene

Rattus norvegicus

Also known as Akap84

Gene ID: 114124 | Gene type: protein coding

About Akap1

Summary

Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of protein dephosphorylation; and negative regulation of protein import into nucleus. Located in several cellular components, including lipid droplet; mitochondrial crista; and neuromuscular junction. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Akap1 Products(1)

mRNA	Protein	Name
NM_053665.1	NP_446117.1	A-kinase anchor protein 1, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	12096916	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	12096916	RGD
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	16756943	RGD
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	16756943	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	9182549	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16996504	RGD
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	16756943	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9722570	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	9722570	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19358331	RGD
involved in negative regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	19358331	RGD
involved in negative regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	19358331	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	16756943	RGD
located in mitochondrial crista	IDA IDA: Inferred from direct assay	16996504	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	11716788	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	11716788	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11716788	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	11716788	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 1, mitochondrial

A kinase (PRKA) anchor protein 1	A-kinase anchor protein 121 kDa
AKAP 121	D-AKAP-1
PRKA1	S-AKAP84
a kinase anchor protein 1, mitochondrial	dual specificity A-kinase-anchoring protein 1
protein kinase A-anchoring protein 1	spermatid A-kinase ancho

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS29476	Akap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00512	AKAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap1	NCBI	NCBI:8165

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