Asic2 - acid-sensing (proton-gated) ion channel 2 Gene

Also Known as BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11418

Summary

Enables ion gated channel activity and ligand-gated Sodium Channel activity. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Asic2 Products (2)

mRNA Protein Name
NM_001034013.2 NP_001029185.1 acid-sensing ion channel 2 isoform MDEG1
NM_007384.3 NP_031410.1 acid-sensing ion channel 2 isoform MDEG2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
9368048 MGI
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
11854527 MGI
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
11854527 MGI
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
18256271 MGI
enables monoatomic ion-gated channel activity IDA
IDA: Inferred from direct assay
14960591 MGI
enables monoatomic ion-gated channel activity IMP
IMP: Inferred from mutant phenotype
14960591 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19571134 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
11069180 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
18256271 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
14960591 MGI
acts upstream of or within monoatomic cation transport IDA
IDA: Inferred from direct assay
11854527 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
11854527 MGI
acts upstream of or within monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
14960591 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14960591 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14762118 MGI
acts upstream of or within phototransduction IMP
IMP: Inferred from mutant phenotype
14762118 MGI
acts upstream of or within positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
19571134 MGI
acts upstream of or within protein localization to synapse IMP
IMP: Inferred from mutant phenotype
19571134 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
19590043 MGI
acts upstream of or within regulation of monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14960591 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
19571134 MGI
involved in regulation of postsynapse assembly IEP
IEP: Inferred from expression pattern
19571134 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
19571134 MGI
acts upstream of or within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
IMP: Inferred from mutant phenotype
20064394 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
18296560 MGI
acts upstream of or within response to acidic pH IDA
IDA: Inferred from direct assay
11306621 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
11854527 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
11069180 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
15537887 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
9368048 MGI
acts upstream of synapse assembly IMP
IMP: Inferred from mutant phenotype
19571134 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
19571134 MGI
located in membrane IDA
IDA: Inferred from direct assay
9368048 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
15537887 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15537887 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11306621 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
19571134 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
19571134 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
19571134 MGI
located in synapse IDA
IDA: Inferred from direct assay
19571134 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid-sensing ion channel 2

  • amiloride-sensitive brain sodium channel

  • amiloride-sensitive cation channel 1, neuronal (degenerin)

  • brain sodium channel 1

  • degenerin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101005 N-Methylhistamine dihydrochloride 99.99% Unkown
HY-P5174 MitTx Activator 98.0% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-P5172 MitTx-alpha Agonist / Unkown
HY-RS01090 ASIC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asic2 NCBI NCBI:40