Asic2 - acid-sensing (proton-gated) ion channel 2 Gene

Mus musculus

Also known as BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a

Gene ID: 11418 | Gene type: protein coding

About Asic2

Summary

Enables ion gated channel activity and ligand-gated Sodium Channel activity. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; and sensory perception of mechanical stimulus. Located in dendritic spine and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system. Orthologous to human ASIC2 (acid sensing ion channel subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Asic2 Products(2)

mRNA	Protein	Name
NM_001034013.2	NP_001029185.1	acid-sensing ion channel 2 isoform MDEG1
NM_007384.3	NP_031410.1	acid-sensing ion channel 2 isoform MDEG2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	9368048	MGI
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11854527	MGI
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	11854527	MGI
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	18256271	MGI
enables monoatomic ion-gated channel activity	IDA IDA: Inferred from direct assay	14960591	MGI
enables monoatomic ion-gated channel activity	IMP IMP: Inferred from mutant phenotype	14960591	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19571134	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within detection of mechanical stimulus involved in sensory perception	IMP IMP: Inferred from mutant phenotype	11069180	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	18256271	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	14960591	MGI
acts upstream of or within monoatomic cation transport	IDA IDA: Inferred from direct assay	11854527	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	11854527	MGI
acts upstream of or within monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	14960591	MGI
acts upstream of or within monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14960591	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	14762118	MGI
acts upstream of or within phototransduction	IMP IMP: Inferred from mutant phenotype	14762118	MGI
acts upstream of or within positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	19571134	MGI
acts upstream of or within protein localization to synapse	IMP IMP: Inferred from mutant phenotype	19571134	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	19590043	MGI
acts upstream of or within regulation of monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14960591	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	19571134	MGI
involved in regulation of postsynapse assembly	IEP IEP: Inferred from expression pattern	19571134	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	19571134	MGI
acts upstream of or within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback	IMP IMP: Inferred from mutant phenotype	20064394	MGI
acts upstream of or within regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	18296560	MGI
acts upstream of or within response to acidic pH	IDA IDA: Inferred from direct assay	11306621	MGI
acts upstream of or within response to acidic pH	IMP IMP: Inferred from mutant phenotype	11854527	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	11069180	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15537887	MGI
acts upstream of or within sodium ion transport	IDA IDA: Inferred from direct assay	9368048	MGI
acts upstream of synapse assembly	IMP IMP: Inferred from mutant phenotype	19571134	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	19571134	MGI
located in membrane	IDA IDA: Inferred from direct assay	9368048	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	15537887	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	15537887	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11306621	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	19571134	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	19571134	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	19571134	MGI
located in synapse	IDA IDA: Inferred from direct assay	19571134	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acid-sensing ion channel 2

amiloride-sensitive brain sodium channel	amiloride-sensitive cation channel 1, neuronal (degenerin)
brain sodium channel 1	degenerin

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5174	MitTx	Activator	98.0%	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-P5172	MitTx-alpha	Agonist	/	Unkown
HY-RS01090	ASIC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asic2	NCBI	NCBI:40

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